BACKGROUND Physicians' financial relationships with the pharmaceutical industry are controversial because such relationships may pose a conflict of interest. It is unknown to what extent industry support of medical education and research influences the opinions and behavior of clinicians and researchers. The recent debate over the safety of calcium-channel antagonists provided an opportunity to...

Yi-Chung Hsieh, Ying-Ru Chen, Err-Lieh Hsu and Rong Kou (2003) Pharmacological effects of calcium channel agtagoinsts on juvenile hormone acid release and intracellular calcium level in the corpora allata of adult male Mythimna loreyi (Lepidoptera: Noctuidae). Zoological Studies 42(2): 336-345. The pharmacological effects of calcium channel antagonists on the in vitro release of juvenile hormon...

The goal of these studies was to determine whether different calcium channel antagonists affect glucose transport in a neuronal cell line. Rat pheochromocytoma (PC-12) cells were treated with L-, T-, and N-type calcium channel antagonists before measurement of accumulation of 2-[(3)H]deoxyglucose (2-[(3)H]DG). The L-type channel antagonists nimodipine, nifedipine, verapamil, and diltiazem all i...

The goal of these studies was to determine if different calcium channel antagonists affect glucose transport in a neuronal cell line. For these studies, rat pheochromocytoma (PC12) cells were treated with L-, Tand N-type calcium channel antagonists prior to measuring the accumulation of H-2-deoxyglucose (H-2-DOG). The L-type channel antagonists, nimodipine, nifedipine, verapamil, and diltiazem ...

To investigate the channels and neurotransmitters in the ventrolateral medulla (VLM) oblongata that are responsible for the maintenance of sympathetic tone and cardio-respiratory reflex regulation. Microinjections of excitant amino acid (glutamate, 100 nl, 100 mM), calcium channel blockers, agonists and antagonists were made throughout the VLM in anaesthetized rats. Arterial blood pressure, sym...

To investigate the channels and neurotransmitters in the ventrolateral medulla (VLM) oblongata that are responsible for the maintenance of sympathetic tone and cardio-respiratory reflex regulation. Microinjections of excitant amino acid (glutamate, 100 nl, 100 mM), calcium channel blockers, agonists and antagonists were made throughout the VLM in anaesthetized rats. Arterial blood pressure, sym...

PC12 cells, a clonal rat pheochromocytoma cell line, possess voltage-dependent calcium channels that bind the high affinity dihydropyridine calcium antagonist [3H]nitrendipine and other calcium channel blockers. The binding is temperature-dependent and saturable, and shows no cooperativity. The calcium antagonists inhibit potassium-induced 45Ca uptake into the cells with approximately the same ...