1. (a) Partial likelihood estimates of the coefficients in the proportional hazards model using , are shown below with standard errors. Those results suggest that, after adjusting for effects of the other variables in the model, patient-donor age interaction ( ), low risk for acute myelotic leukemia ( ) and the FAB morphology score ( ) have significant associations with disease free survival. 1...

2. In a study of the effects of treating multiple sclerosis patients with human fibroblast interferon (IFN-B) (reported by Jacobs, O'Malley, Freeman, and Ekes (1981), Science, 214, pp. 1026-1028), 20 multiple sclerosis patients were randomly divided into a group of 10 IFN-B recipients and a group of 10 controls. At the beginning of the study the severity of each patient's symptoms was evaluated...

Increased concentrations of bilirubin glucuronides in blood plasma indicate hepatocellular dysfunction. Elucidation of the transport processes of bilirubin conjugates across the basolateral (sinusoidal) and the canalicular plasma membrane domains of hepatocytes has decisively contributed to our current understanding of the molecular basis of conjugated hyperbilirubinemia in human liver diseases...

Background: A direct relation exists between sodium and calcium excretion, but randomized studies evaluating the sustained effect of a low-salt diet on idiopathic hypercalciuria, one of the main risk factors for calcium-oxalate stone formation, are still lacking. Objective: Our goal was to evaluate the effect of a low-salt diet on urinary calcium excretion in patients affected by idiopathic cal...

A short abstract not more than c. 150 words should be submitted on a separate page. An article abstract should indicate the scope and the main points of the article. A report abstract should indicate the scope of the report, the methods used, and main results. Synopses should not have an abstract. Numerals and Units of Measure Use thousand million instead of billion or use 109. Run together num...

Example. Every non-zero element of ⋀ V is trivially totally decomposable. Example. If dimV = 3, then every non-zero element of ⋀ V is totally decomposable. Proof. Given a sum v1 ∧v2 +v3 ∧v4 of two non-zero elements of ⋀ V , the two-dimensional subspaces Span(v1, v2) and Span(v3, v4) must intersect. If w1 is in the intersection, then we can rewrite v1∧v2 = w1 ∧w2 for some w1 ∈ Span(v1, v2). Simi...

MEDI-565 (also known as MT111) is a bispecific T-cell engager (BiTE®) antibody in development for the treatment of patients with cancers expressing carcinoembryonic antigen (CEA). MEDI-565 binds CEA on cancer cells and CD3 on T cells to induce T-cell mediated killing of cancer cells. To understand the molecular basis of human CEA recognition by MEDI-565 and how polymorphisms and spliced forms o...

Sujin Kang1,2, Toshio Tanaka1,2, Kazuya Masuda3 and Tadamitsu Kishimoto3* 1Department of Clinical Application of Biologics, Osaka University Graduate School of Medicine, 2-2 Yamada-oka, Suita, Osaka 565-0871, Japan 2Department of Respiratory Medicine, Allergy and Rheumatic Diseases, Osaka University Graduate School of Medicine, 2-2 Yamada-oka, Suita, Osaka 565-0871, Japan 3Laboratory of Immune ...