background: bone morphogenetic protein 2 (bmp- 2) belongs to the tgf-β superfamily of proteins and plays an important role in the development of bone and cartilage. bmp- 2 is also associated with maintenance and repair of damaged bone. recombinant human bone morphogenetic protein 2 (rhbmp- 2) is now produced by genetic engineering techniques and used in treatment of thin bone fractures in the j...

introduction : surgical repair of cleft palate with a bony bridge may offer some distinct advantages including a lower rate of fistula formation. the goal of this study was to evaluate the feasibility of surgically inducing cleft palate and reconstruction of the cleft with the use of bone morphogenetic protein-2 (bmp-2) in sheep. materials and methods : in the control group (two sheep), the cle...

conclusions the results of the first human pharmacokinetic studies of aminorex were first characterized in 2013. the results suggest that while humans could produce aminorex from levamisole, they probably do not convert very much. even though cases of pah have been reported in cocaine users, the latest pharmacokinetic studies suggest that very little aminorex is actually produced from the inges...

objective: bone morphogenetic protein-7 (bmp-7) is a multifunctional growth factor predominantly recognized for its osteoinductive properties. due to the high cost of this protein, the availability of bmp-7 for treatment is limited. the heterologous production of recombinant hbmp-7 has been performed in a number of expression systems. in this study a novel form of bmp-7 was expressed in eukaryo...

background: mesenchymal stem cells (mscs) are multipotent cells that can be collected from different sources. under specific conditions, mscs can be differentiated to tissue specific cells in vitro. human umbilical cord mesenchymal stem cells (hucmscs) can easily be harvested and cultured in in vitro conditions. production of germ cells from mesenchymal stem cells is a very interesting and prom...

background: bone morphogenetic proteins (bmps) belong to the transforming growth factor-β (tgf-β) superfamily, and play an important role in bone metabolism. recombinant forms of bmp-2 and bmp-7 are the only bmps used clinically. in this study the mature part of human bone morphogenetic protein-7 (bmp-7) was engineered through substitution of the bmp-7 n-terminal sequence by heparin-binding sit...

Bone Regeneration In article 2201886 by Huaqiong Li and co-workers, human hair keratin is proposed as an organic binder for the simultaneous incorporation of bone's major inorganic component, hydroxyapatite, growth factor, recombinant bone morphogenetic protein 2 (rhBMP2), to enable both osteoconductive osteoinductive characteristics in creation scaffolds.

Bone is a major storage site for TGFbeta superfamily members, including TGFbeta and bone morphogenetic proteins. It is believed that these cytokines are released from bone during bone resorption. Recent studies have shown that both RANKL and macrophage colony-stimulating factor are two essential factors produced by osteoblasts for inducing osteoclast differentiation. In the present study we exa...