Hepatic biotransformation of bilirubin to the hydrophilic species bilirubin mono- (BMG) and diglucuronide (BDG) by microsomal bilirubin UDP-glucuronosyl-transferase (GT) is a prerequisite for its physiologic excretion into bile. The reaction mechanism of bilirubin-GT and the access of bilirubin and BMG (the intermediate substrate) to the active site of bilirubin-GT are undefined. Highly purifie...

introduction: osseous tissue developes via either endochondral (ec) or intramemberanous (im) ossification. the bone matrix gelatin (bmg) from both developmental types can induce bone formation when implanted in the muscle of the rat. in this research, the resorption of im-bmg particles, inductivity of im-bmg and the nature of heterotropic calcification was evaluated at implantation site. materi...

bone matrix gelatin (bmg) has been used for bone induction intramuscularly and subcutaneously by many investigators since 1965. more recently, some of the researchers have used bmg particles for bone repair and reported various results. in present study for evaluation of bone induction and new bone formation in parital defects, bmg particles were used in five groups of rats. the bmg was prepare...

OBJECTIVE The aim of this study was to compare the outcomes of dorsal onlay urethroplasty using buccal mucosa graft (BMG) versus penile skin flap (PSF) in the repair of long anterior urethral strictures. MATERIAL AND METHODS Patients with long anterior urethral strictures were randomized to receive either dorsal onlay BMG urethroplasty or PSF urethroplasty. All patients were evaluated preoper...

Mechanisms for transport of bilirubin and its conjugates in hepatocytes have not been defined. We investigated the hepatic processing of bilirubin glucuronides and their precursors, and characterized the disposition of bile pigments arising from intraversus extrahepatic sources. Tracer doses of purified radiolabeled biliverdin, bilirubin, bilirubin monoglucuronide (BMG) or diglucuronide (BDG) w...