The effect of pretreatment with the calcium antagonist nimodipine on the pathophysiological events which follow an intracerebral haemorrhage in rats was compared with a similar control group. Cerebral blood flow was higher and the amount of pathologically determined ischaemic damage measured by light microscopy was less in the nimodipine pretreated group. Bloodbrain barrier permeability was inc...

Increased permeability or " breakdown " of the bloodbrain barrier following the carotid injection of various contrast media has been previously documented [1 -6]. Trans ient opening of the blood-brain barrier may also be produced by injecting hyperosmotic mannitol or arabinose into th e interna l carotid artery [7 -12]. CT scanning has recently been appli ed to the definition and quantitation o...

Sysyn, Gregory D., Katherine H. Petersson, Clifford S. Patlak, Grazyna B. Sadowska, and Barbara S. Stonestreet. Effects of postnatal dexamethasone on bloodbrain barrier permeability and brain water content in newborn lambs. Am J Physiol Regulatory Integrative Comp Physiol 280: R547–R553, 2001.—We showed that antenatal corticosteroids reduced blood-brain barrier permeability in fetuses at 60 and...

Sysyn, Gregory D., Katherine H. Petersson, Clifford S. Patlak, Grazyna B. Sadowska, and Barbara S. Stonestreet. Effects of postnatal dexamethasone on bloodbrain barrier permeability and brain water content in newborn lambs. Am J Physiol Regulatory Integrative Comp Physiol 280: R547–R553, 2001.—We showed that antenatal corticosteroids reduced blood-brain barrier permeability in fetuses at 60 and...

Tissue-type plasminogen activator (t-PA) can modulate permeability of the neurovascular unit and exacerbate injury in ischemic stroke. We examined the effects of t-PA using in vitro models of the bloodbrain barrier. t-PA caused a concentrationdependent increase in permeability. This effect was dependent on plasmin formation and potentiated in the presence of plasminogen. An inactive t-PA varian...

Background/introduction While most brain tumors do not have an intact bloodbrain barrier (BBB), vascular barriers in the tumor and the surrounding intact brain tissue are major challenges for the use of chemotherapy for CNS malignancies. The permeability of brain tumor vessels can be highly heterogeneous, and factors such as high interstitial pressures can prevent agents from reaching an effect...

Background: Plant N-alkylamides (NAAs) are bio-active compounds with a broad functional spectrum. In order to reach their pharmacodynamic targets, they have to overcome several barriers of the body in the absorption phase. The permeability kinetics of spilanthol (a diene NAA) and pellitorine (a triene NAA) across these barriers (i.e. skin, oral/gut mucosa, bloodbrain barrier) were investigated....

generally used for diagnostic and interventional cerebral angiography. Several cases with minor complications resulting from nonionic CM have been reported (1-4). Regarding adverse events of CM, abnormal contrast enhancement have frequently been encountered up to 43% in clinical practices, and appearance of these patterns on CT scans can be various such as cortical, subarachnoid, intraventricul...

Rats were exposed to 1.3 gHz microwave energy to assess the uptake of several neutral polar substances in certain areas of the brain. A quantitative, radioactive isotope method, which uses an internal standard, was employed to measure the loss of test substances to brain tissue. Single, 20 min exposure, to either pulsed or continuous wave (CW) microwave energy induced an increase in the uptake ...