Ab stract More than 1500 shell or na ments were re cov ered dur ing the ex ca va tions of the early Up per Paleolithic through Mesolithic lay ers of Klissoura Cave 1. The or na ment as sem blages from the mid dle and lower Aurig na cian and the ear li est Up per Paleolithic (Uluzzian) lay ers as so ci ate with well pre served hearths and other in tact cul tural fea tures. The older or na ment a...

GES-type enzymes belong to Ambler Class A plasmidencoded -lactamases. Although GES enzymes usually exhibit extended-spectrum -lactamases (ESBL) properties, changes in its active site enhance its activity conferring the ability to hydrolyze carbapenems.1 GES-type carbapenemases (GES2, GES-4, GES-5, GES-8, GES-11, GES-18, GES-20) have already been described in several countries.2 Although it has ...

BACKGROUND Nosocomial infections caused by Pseudomonas aeruginosa presenting resistance to beta-lactam drugs are one of the most challenging targets for antimicrobial therapy, leading to substantial increase in mortality rates in hospitals worldwide. In this context, P. aeruginosa harboring acquired mechanisms of resistance, such as production of metallo-beta-lactamase (MBLs) and extended-spect...

High Incidence of MDR and XDR Pseudomonas aeruginosa Isolates Harboring blaGES, blaVEB, blaPER Extended-Spectrum Beta-Lactamase Genes in Iran

Multidrug-resistant and difficult-to-treat Acinetobacter baumannii may be responsible for nosocomial infections. The production of carbapenem-hydrolyzing class D β-lactamases (CHDLs) and extended-spectrum β-lactamase (ESBLs) of the GES type possessing a carbapenemase activity has been increasingly reported worldwide in A. baumannii. The aim of this study was to analyze the resistance mechanisms...

Previous analysis of Pseudomonas aeruginosa class-1 integrons from Rio de Janeiro, Brazil, revealed the blaGES gene in one isolate. We screened isolates of two widespread PFGE genotypes, A and B, at a public hospital in Rio, for the presence of blaGES. The gene was detected in all seven P. aeruginosa isolates belonging to genotype B. Three of the seven genotype-B isolates were resistant to amik...

background guiana extended-spectrum (ges-2) as one of the extended-spectrum β-lactamases (esbls), produced by pseudomonas aeruginosa, is able to compromise the effectiveness of imipenem and tends to be geographically limited. objectives the aim of this study was to detect the spread of ges-2 β-lactamase gene among esbl- producing p. aeruginosa isolates in a teaching hospital in kashan, iran. ma...