نتایج جستجو برای: bithiazoles
تعداد نتایج: 12 فیلتر نتایج به سال:
Conformationally constrained bithiazoles were previously found to have improved efficacy over nonconstrained bithiazoles for correction of defective cellular processing of the ΔF508 mutant cystic fibrosis transmembrane conductance regulator (CFTR) protein. In this study, two sets of constrained bithiazoles were designed, synthesized, and tested in vitro using ΔF508-CFTR expressing epithelial ce...
Bridged bithiazoles (5,5'-ethylene-4,4'-bithiazoles) are synthesized as a good chelating agent.
bridged bithiazoles (5,5'-ethylene-4,4'-bithiazoles) are synthesized as a good chelating agent.
plexes of amines and cyclic amines used as DNA cleavage agents have been reported. These compounds generally contain heterocycles or polycyclic aromatic rings tethered to one or more aminoalkyl side chains, and are complexed with transition metals known to play important roles in DNA cleavage reactions. Many studies on the role of 2,4 -bithiazole, which constitutes a part of the C-terminus of B...
Better correctors are needed to repair cystic fibrosis transmembrane conductance regulator (CFTR) processing mutants that cause cystic fibrosis. Determining where the correctors bind to CFTR would aid in the development of new correctors. A recent study reported that the second nucleotide-binding domain (NBD2) was involved in binding of bithiazole correctors. Here, we show that bithiazole corre...
The bleomycins (BLMs) are natural products that in the presence of iron and oxygen bind to and cause single-strand and double-strand cleavage of DNA. The mode(s) of binding of the FeBLMs that leads to sequence-specific cleavage at pyrimidines 3' to guanines and chemical-specific cleavage at the C-4' H of the deoxyribose of the pyrimidine has remained controversial. 2D NMR studies using the hydr...
نمودار تعداد نتایج جستجو در هر سال
با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید