نتایج جستجو برای: bethesda units.

تعداد نتایج: 175860  

Journal: :iranian journal of blood and cancer 0
mohsin sh jaffar j hussain sh suhail sh ikram ullah m amjad s

background: factor viii administration to hemophilia a patients results in an immune response (inhibitor formation) which significantly complicates the therapy. the present study was performed to determine the prevalence of inhibitor development in hemophilia a patients receiving recombinant factor viii therapy. materials and methods: this was an observational descriptive study. clotting factor...

Amjad S, Hussain Sh, Ikram Ullah M, Jaffar J, Mohsin Sh, Suhail Sh,

Background: Factor VIII administration to hemophilia A patients results in an immune response (inhibitor formation) which significantly complicates the therapy. The present study was performed to determine the prevalence of inhibitor development in hemophilia A patients receiving recombinant factor VIII therapy. Materials and Methods: This was an observational descriptive study. Clotting fac...

Journal: :Blood 1993
A E Morrison C A Ludlam C Kessler

Data have been collected from 47 centers in Europe and North America on the treatment with porcine factor VIII concentrate of 74 acute bleeding episodes in 65 patients with acquired hemophilia. The median initial anti-human factor VIII auto-antibody inhibitor level was 38 Bethesda unit (BU)/mL (range 1.2 to 1,024) whereas that against porcine was 1 BU/mL (range 0 to 15). The mean initial dose o...

Journal: :Blood 1995
R S Schwartz D A Gabriel L M Aledort D Green C M Kessler

A decrease in inhibitor titer has been reported in some patients with acquired factor VIII inhibitors treated with intravenous gammaglobulin (IGIV). We have conducted a prospective, multicenter study of high-dose IGIV in treatment of this disorder to determine efficacy. Nineteen patients received induction therapy with IGIV, 1,000 mg/kg x 2 consecutive days or 400 mg/kg x 5 consecutive days, fo...

Journal: :Blood 2002
Adrian Wiestner Hearn J Cho Adam S Asch Mary Ann Michelis Jack A Zeller Ellinor I B Peerschke Babette B Weksler Geraldine P Schechter

Autoantibodies against factor VIII (FVIII) are rare but can cause life-threatening bleeding requiring costly factor replacement and prolonged immunosuppression. We report 4 consecutively treated patients whose acquired FVIII inhibitors responded rapidly to immunosuppressive regimens that included rituximab, a monoclonal antibody against CD20(+) B cells. Three patients had spontaneously occurrin...

2010
Ching-Yin Chen Ya-Hui Chen Ji-Chen Ho Chieh-Shan Wu

daily for 1 week), pulse therapy with methylprednisolone (1000 mg/day for 3 days) and rituximab (100 mg/week for 2 weeks) were initially used for correcting the coagulopathy. Prednisolone (1 mg/kg/day) and cyclophosphamide (100 mg/ day) were prescribed as maintenance therapy. The coagulatory disorder improved after 2 months of treatment associated with reduction of factor VIII inhibitor to 35 B...

Journal: :Journal of the College of Physicians and Surgeons--Pakistan : JCPSP 2012
Munira Borhany Meena Kumari Tahir Shamsi Arshi Naz Tasneem Farzana

OBJECTIVE To determine the frequency of factor VIII specific inhibitors in haemophilia A. STUDY DESIGN Cross-sectional study. PLACE AND DURATION OF STUDY National Institute of Blood Disease and Bone Marrow Transplantation, Karachi, from August 2007 to March 2009. METHODOLOGY Venous blood samples of diagnosed haemophilia A patients were collected in tubes containing 0.109 M (3.2%) trisodiu...

2015
Caileen M. Brison Steven M. Mullen Michelle E. Wuerth Kira Podolsky Matthew Cook Jacob A. Herman Justin D. Walter Shannon L. Meeks P. Clint Spiegel

The factor VIII C2 domain is essential for binding to activated platelet surfaces as well as the cofactor activity of factor VIII in blood coagulation. Inhibitory antibodies against the C2 domain commonly develop following factor VIII replacement therapy for hemophilia A patients, or they may spontaneously arise in cases of acquired hemophilia. Porcine factor VIII is an effective therapeutic fo...

Journal: :Blood 1977
T S Lossing C K Kasper D I Feinstein

Variations of the partial thromboplastin time (PTT) were tested to determine the best screening method for detection of inhibitors of factor VIII. Variables tested included the duration of preincubation of a mixture of patient plasma and factor VIII source (normal plasma), the ratio of the patient plasma to the normal plasma, and the duration of incubation of the normal plasma-patient plasma mi...

Journal: :Journal of Periodontal & Implant Science 2016

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