The in vivo expression of the Epstein-Barr virus (EBV) BamHI-A rightward transcripts (BARTs) as well as the putative BART-encoded BARF0 and RK-BARF0 proteins in various EBV-associated malignancies was investigated. RT-PCRs specific for the different splice variants of the BARTs and both a nucleic acid sequence-based amplification assay and an RT-PCR specific for the BARF0 ORF were used. Abundan...

1Division of Haemato-Oncology and Immunophenotyping Section, Department of Haematology, Barts and The London National Health Service (NHS) Trust, London, United Kingdom; 2Blizard Institute of Cell and Molecular Sciences, Queen Mary University of London, London, United Kingdom; 3Laboratoire de Thérapie Cellulaire, Institut Jean Godinot, Reims, France; 4Centre for Haemato-Oncology, Barts Cancer I...

UNLABELLED Epstein-Barr virus (EBV) expresses few viral proteins in nasopharyngeal carcinoma (NPC) but high levels of BamHI-A rightward transcripts (BARTs), which include long noncoding RNAs (lncRNAs) and BART microRNAs (miRNAs). It is hypothesized that the mechanism for regulation of BARTs may relate to EBV pathogenesis in NPC. We showed that nuclear factor-κB (NF-κB) activates the BART promot...

David Wrench, Rachel Waters, Emanuela Carlotti, Sameena Iqbal, Janet Matthews, Marie Calaminici, John Gribben, T Andrew Lister, Jude Fitzgibbon Centre for Medical Oncology, Barts and the London School of Medicine, London, UK; Centre for Statistics in Medicine, University of Oxford, Oxford, UK; Data Management Unit, Medical Oncology Department, Barts and the London NHS Trust, London, UK; Histopa...

| 150 | haematologica | 2009; 94(1) MDM2 SNP 309 can lead to earlier onset or more advanced disease and TP53 negatively regulates MDM2 expression, we assessed MDM2 SNP 309 alleles in isolation or in combination with TP53 Arg72Pro alleles against these clinical parameters; there was no evidence of any association (illustrated in Table 1 for gender, stage and responses to therapy; p≥0.13). Kaplan...

King’s College Hospital, St Mary’s Hospital, Barts and The London Hospital, London, Birmingham Children’s Hospital, Birmingham, Barts and The London School of Medicine and Dentistry, St George’s Hospital, London, Queen Elizabeth Hospital, King’s Lynn, Norfolk, Ashford Hospital, Middlesex, London, Patient representative, St Helier Hospital, Carshalton, Surrey, Royal Bournemouth Hospital, Dorset,...

Epstein-Barr virus (EBV) is a ubiquitous human γ-herpesvirus that can give rise to cancers of both B-cell and epithelial cell origin. In EBV-induced cancers of epithelial origin, including nasopharyngeal carcinomas (NPCs) and gastric carcinomas, the latent EBV genome expresses very high levels of a cluster of 22 viral pre-miRNAs, called the miR-BARTs, and these have previously been shown to con...

Author details Department of Women’s Cancer, EGA Institute for Women’s Health, University College London, London, UK. Health Behaviour Research Centre, Department of Epidemiology & Public Health, University College London, London, UK. Department of Gynaecological Oncology, Barts Health NHS Trust, Royal London Hospital, London, UK. Barts Cancer Institute, Queen Mary University of London, London,...