Introduction: The bed nucleus of the stria terminalis (BST) is a limbic structure which is involved in cardiovascular regulation and baroreflex modulation. The presence of cholinergic synaptic terminalis with high level of muscarinic receptors in the BST has been demonstrated. This study was performed to find the role of the cholinergic muscarinic receptor in cardiovascular response and baro...

introduction: the bed nucleus of the stria terminalis (bst) is a limbic structure which is involved in cardiovascular regulation and baroreflex modulation. the presence of cholinergic synaptic terminalis with high level of muscarinic receptors in the bst has been demonstrated. this study was performed to find the role of the cholinergic muscarinic receptor in cardiovascular response and baroref...

#### Notable in Neurology This Week issue features a Research Article that investigates arousal mechanisms patients with severe traumatic brain injury; another examines the association between pathologic variants CHRNA3 gene and familial autonomic ganglionopathy diffuse failure. An American Academy of Position Statement outlines ethical considerations diagnosis care people dementia. ### Natural...

introduction: cisplatin (cp) therapy may disturb cardiovascular system control. the objective of this study was to find baroreflex sensitivity (brs) in cp-induced nephrotoxicity in rats. materials and methods: eighteen male and female wistar rats were randomly assigned to two groups treated with cp (2.5 mg/kg/day) and the vehicle, for five consecutive days, and then were subjected to surgical p...

Previous studies showed that a proportion of normotensive Sprague-Dawley rats spontaneously exhibit lower baroreflex sensitivity. However, investigations have not yet been carried out on Wistar rats. We aimed to compare baroreflex sensitivity among rats from the same strain and the same laboratory. Male Wistar normotensive rats (300-400g) were studied. Cannulas were inserted into the abdominal ...

OBJECTIVES A subset of normotensive Sprague-Dawley rats show lower baroreflex sensitivity; however, no previous study investigated whether there are differences in baroreflex sensitivity within this subset. Our study compared baroreflex sensitivity among conscious rats of this specific subtype. METHODS Male Wistar Kyoto (WKY) rats (16 weeks old) were studied. Cannulas were inserted into the a...

BACKGROUND The overall effect of vasoactive drugs on blood pressure is determined by a combination of the direct effect on vascular tone and an indirect baroreflex-mediated effect, a baroreflex buffering of blood pressure. Differences in baroreflex function affect the responsiveness to vasoactive medications, particularly baroreflex buffering of blood pressure; however, the magnitude is not kno...

Spontaneously occurring, parallel fluctuations in arterial pressure and heart period are frequently used as indices of baroreflex function. Despite the convenience of spontaneous indices, their relation to the arterial baroreflex remains unclear. Therefore, in 97 volunteers, we derived 5 proposed indices (sequence method, alpha-index, transfer function, low-frequency transfer function, and impu...