Background and Objective: Helicobacter pylori has several strains with different degrees of virulence. The aim of this study was to detect two major important virulence factors, cagA/vacA genotypes, and to determine correlations among different cagA/vacA genotypes and histological features of chronic gastritis in Iranian patients. Methods: In this cross- sectional study, Gastric bi...

introduction and aims: helicobacter pylori commonly is associated with gastritis: but only sometimes it causes clinically significant diseases such as gastric and duodenal ulcer. the development of disease depends on the virulence of the infecting h. pylori strain, the susceptibility of the host, and environment co-factors. the cytotoxin associated protein encoded by caga gene is an important v...

conclusions results indicates that antigenic region of recombinant caga protein were recognized as an antigen , so it might be a candidate for the development of h. pylori vaccine, elisa kit designs and serological diagnosis of h. pylori infections. background helicobacter pylori is a human pathogen that causes chronic gastritis, which playsrole in gastric and duodenal ulcers, is also involved ...

background and objective: helicobacter pylori has several strains with different degrees of virulence. the aim of this study was to detect two major important virulence factors, caga/vaca genotypes, and to determine correlations among different caga/vaca genotypes and histological features of chronic gastritis in iranian patients. methods: in this cross- sectional study, gastric biopsy was take...

Background: Cytotoxin-associated gene A (CagA)-positive strains of Helicobacter pylori are associated with gastroduodenal diseases. Evidences have suggested that the type of H pylori CagA EPIYA motifs may be associated with specific disorders (i.e., gastritis, peptic ulcer, or gastric cancer).  We investigated the prevalence of different EPIYA motifs (A, B, C, or D) in H. pylori strains is...

conclusions about 90% of h. pylori strains potentially contained vaca s2m2 and s1m2 genotypes. infection with h. pylori strain containing the caga gene or the vaca s1m1 and s1m2 genotypes was associated with increased incidence of peptic ulcer disease (pud). objectives the aim of this study was to determine the frequency of two toxins and genotypes of vaca toxin in patients referred to a centra...

abstract: introduction & objective: helicobacter pylori are among the important pathogens responsible for chronic gastritis, peptic ulcer and gastric cancer. the present study aimed to comparatively evaluate pcr and rut methods for detection of h. pylori and determination of the prevalence of the cagapositive helicobacter pylori strains in shahrekord. materials & methods: this is a molecular ep...

background : data concerning the information on the prevalence and association of the helicobacter pylori cytotoxinassociated gene a (caga) with disease is still controversial. the aim of this study was to isolate and identify h. pylori by culture methode from biopsy specimens and its relationship with associated diseases by molecular techniques (pcr). materials and methods: gastric biopsy spec...

conclusions using the pcr-rflp method, three distinctive h. pylori caga genotypes were detected in antral biopsies. genotype i, which was predominant among the isolates, was significantly associated with gastritis. however, the data showed that caga genotype iii may play a role in duodenitis and duodenal ulcers in patients infected with h. pylori. patients and methods a total of 161 gastric bio...

CagA, encoded by cytotoxin-associated gene A (cagA), is a major virulence factor of Helicobacter pylori, a gastric pathogen involved in the development of upper gastrointestinal diseases. Infection with cagA-positive H. pylori may also be associated with diseases outside the stomach, although the mechanisms through which H. pylori infection promotes extragastric diseases remain unknown. Here, w...