Two effective cytochrome P450 (CYP) inhibitors were isolated from tarragon, Artemisia dracunculus. Their structures were spectroscopically identified as 2E,4E-undeca-2,4-diene-8,10-diynoic acid isobutylamide (1) and 2E,4E-undeca-2,4-diene-8,10-diynoic acid piperidide (2). Both compounds had dose-dependent inhibitory effects on CYP3A4 activity with IC50 values of 10.0 ± 1.3 µM for compound 1 and...

The essential oil isolated from Turkish tarragon (Artemisia dracunculus) by hydrodistillation was analyzed by GC-MS. Thirty compounds representing 99.5% of total oil were identified. The predominant components in the oil were (Z)-anethole (81.0%), (Z)-beta-ocimene (6.5%), (E)-beta-ocimene (3.1%), limonene (3.1%), and methyleugenol (1.8%). The antibacterial and antifungal activities of the essen...

methods the mice were divided into six groups including a normal control group, a placebo group, and three treatment groups receiving 50, 100, and 200 mg/kg doses of hydroalcoholic extract via intraperitoneal (ip) injection followed by inoculation with c. albicans. a control+ group, inoculated only with c. albicans, was also employed. after all treatments, the mice were killed by cervical decap...

Artemisia dracunculus L. (tarragon) has a long history of use as a spice and remedy. Two well-described "cultivars" (Russian and French) are used widely and differ in ploidy level, morphology, and chemistry. Key biologically active secondary metabolites are essential oils (0.15-3.1%), coumarins (>1%), flavonoids, and phenolcarbonic acids. In vivo studies mainly in rodents, particularly from Ru...

this study was designed to investigate the effects of different levels of tarragon powder on performance, carcass characteristics of broiler chickens. two hundred ross 308 male broiler chickens were randomly allocated into four treatments and five replicates per treatment. at each replicate ten birds were used. experimental diets were set on the basis of corn-soy-wheat and ross 308 broiler chic...

Background It has previously been shown that the plasma concentration of creatine following supplementation is influenced by extracellular concentrations of insulin and glucose, the form in which creatine is administered, and also the creatine concentration in the muscle cells. The common practice of raising insulin levels to increase initial uptake into muscle, by means of high amounts of gluc...

Objective: Plant extracts are of considerable interest because of their antiepileptic activities. However, the mechanisms of action are not clearly defined. Materials and Methods: Here, the effects of Artemisia dracunculus L. (tarragon) leaves extract on excitability and electrophysiological characteristics of snail neurones were investigated, using an intracellular recording technique. Results...