this review provides the basic principle and rational for roc analysis of rating and continuous diagnostic test results versus a gold standard. derived indexes of accuracy, in particular area under the curve (auc) has a meaningful interpretation for disease classification from healthy subjects. the methods of estimate of auc and its testing in single diagnostic test and also comparative studies...

For many years now, there is a growing interest around ROC curve for characterizing machine learning performances. This is particularly due to the fact that in real-world problems misclassification costs are not known and thus, ROC curve and related metrics such as the Area Under ROC curve (AUC) can be a more meaningful performance measures. In this paper, we propose a quadratic programming bas...

We show that any weak ranker that can achieve an area under the ROC curve slightly better than 1/2 (which can be achieved by random guessing) can be efficiently boosted to achieve an area under the ROC curve arbitrarily close to 1. We further show that this boosting can be performed even in the presence of independent misclassification noise, given access to a noise-tolerant weak ranker.

BACKGROUND Modeling studies using hypothetical polygenic risk data can be an efficient tool for investigating the effectiveness of downstream applications such as targeting interventions to risk groups to justify whether empirical investigation is warranted. We investigated the assumptions underlying a method that simulates risk data for specific values of the area under the receiver operating ...

We introduce a new smooth estimator of the ROC curve based on log-concave density estimates of the constituent distributions. We show that our estimate is asymptotically equivalent to the empirical ROC curve if the underlying densities are in fact log-concave. In addition, we empirically show that our proposed estimator exhibits an efficiency gain for finite sample sizes with respect to the sta...

We introduce the Skill Plot, a method that it is directly relevant to a decision maker who must use a diagnostic test. In contrast to ROC curves, the skill curve allows easy graphical inspection of the optimal cutoff or decision rule for a diagnostic test. The skill curve and test also determine whether diagnoses based on this cutoff improve upon a naive forecast (of always present or of always...