background: silymarin is a flavonolignan that has been the subject of research to evaluate the beneficial properties for decades. silymarin has been known for its potent cytoprotective, hepatoprotective and antioxidant activities. the goal of the present study was to gain a deeper understanding of possible molecular mechanisms of apoptosis of the injuries induced by silymarin on balb/c mice fet...

objective(s): the role of aluminum (al) in the pathogenesis of neurodegenerative diseases has been implicated in several studies. however, the exact mechanisms of cytotoxic effects of al have not been elucidated yet. the aim of this study was to investigate the effect of l-type calcium channel antagonist, nimodipine (nm), and lithium chloride (licl) on al-induced toxicity in pc12 cells. materia...

background: there is accumulating evidence that a polyphenol present in olive oil, oleuropein, has antioxidant, anti-inflammatory and anti-apoptotic effects. this study aimed at determining the anti-apoptotic effect of oleuropein (ole) on dexamethasone-induced apoptosis of mouse thymocytes. method: mice were randomly divided to four groups as follow: dexamethasone (dex)-treated group (20 mg/kg;...

background physical activity and alteration of temperature as a source of stress may have adverse effects on male reproduction. objectives the aim of this study was to investigate the effect of chronic swimming and standing in cold, warm and lukewarm water on mouse spermatogenesis. materials and methods forty-nine male mice (n = 49) were randomly divided into seven groups: c, control; swc, swim...

cirrhosis is associated with hyperdynamic circulation, manifesting as increased cardiac output and decreased systemic vascular resistance. the aim of this study was to investigate the effect of cirrhosis on heart apoptosis and involvement of nitric oxide (no) and oxidative stress in the possible altered apoptosis of cirrhotic hearts. twenty-eight days after bile duct ligation, heart tissues wer...

background apoptosis or programmed cell death is an essential process for elimination of damaged cells. also, induction of apoptosis is fundamental for treating cancer. screening for agents that induce apoptosis in tumor cells help in the development of novel agents for cancer treatment. numerous studies suggest that the exposure of tumor cells to statins can lead to cell death via two separate...

background apoptosis is a physiological mechanism of cell death and it can be triggered by a variety of internal and external stimuli. it has been indicated that some opium derivatives develop cell apoptosis. objectives the aim of this investigation was to evaluate the effect of opium addiction on ovary cell apoptosis in diabetic and non-diabetic wistar rats. materials and methods this experime...

conclusions artemether especially in oral treatment is an effective and simple method and may be used as a new method to treat visceral leishmaniasis. results ic50 of the drug on leishmania infantum was determined to be 25 μg/ml after 24 h. in vivo experiments indicated that oral artemether treatment of mice, during 3 days and every 6 h (0.625 mg/kg) was more significant than parenteral (0.625 ...

background: oocyte cryopreservation is one of the most important topics in the field of assisted reproductive technology to preserve women fertility, but relationship between cryopreservation and apoptosis is still a matter of debate. the present study was aimed to investigate the effects of vitrification on apoptosis in mouse oocytes by cryotop method. method: a total of 200 germinal vesicle (...