The purpose of this work was to explore the particle size reduction effect of carvedilol on dissolution and absorption. Three suspensions containing different sized particles were prepared by antisolvent precipitation method or in combination with an ultrasonication process. The suspensions were characterized for particle size, surface morphology, and crystalline state. The crystalline form of ...

The novel methotrexate-loaded nanoparticles (MTX/PGD NPs) prepared with amphiphilic codendrimer PGD from polyamidoamine and oligothylene glycol dendrons were obtained via antisolvent precipitation method augmented by ultrasonication. Based on the excellent hydrophility of PGD, the drug-loaded nanoparticles could be investigated easily with the high drug-loading content (~85.2%, w/w). The MTX/PG...

The objective of the study was to prepare vinblastine microparticles by supercritical antisolvent process using N-methyl-2-pyrrolidone as solvent and carbon dioxide as antisolvent and evaluate its physicochemical properties. The effects of four process variables, pressure, temperature, drug concentration and drug solution flow rate, on drug particle formation during the supercritical antisolven...

This paper presents the fabrication of controlled release devices for anticancer drug paclitaxel using supercritical antisolvent method. The thermodynamic and hydrodynamic effects during supercritical antisolvent process on the particle properties obtained were investigated. Scanning electron microscopy was employed to study particle sizes and morphologies achieved. It was observed that increas...

An enzymatic biotransformation process based on extracted pyruvate decarboxylase (PDC) overcomes the problem of by-product benzyl alcohol production. Seven methods of cells disruption which included application of glass beads, freezing/thawing sequence, silver nanoparticles, ultrasonication, freezing/thawing sequence with glass beads, freezing/thawing sequence with silver nanoparticles, and fre...

Due to its low bioavailability and slow dissolution rate, the micronized spiramycin powder was thus prepared by the homogenate-antisolvent precipitation (HAP) process. The optimum micronization conditions of the HAP process were found to be as follows: precipitation temperature of 4.6 ◦C, precipitation time of 10 min, spiramycin concentration of 20 mg/mL, dripping speed of the added solvent int...

Microporous polyvinylidene fluoride (PVDF) and PVDF nanocomposite membranes were prepared via an isothermal immersion precipitation method using two different antisolvents (ethanol and water). The structure and morphology of the resulting membranes were investigated by wide angle X-ray diffraction (WAXD), Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), and di...

We developed a novel anti-agglomeration method that enables preservation of the vertical alignment of carbon nanotubes (CNTs) during desiccation of wet CNTs by utilizing antisolvent precipitation and sublimation of naphthalene (Nap). Moreover, we succeeded in depositing Pt nanoparticles onto CNTs without collapse of the vertically aligned morphology by this method.

Purpose: To prepare and optimize esomeprazole nanosuspension to enhance drug dissolution rate. Methods: Esomeprazole nanosuspensions were prepared by evaporative precipitation-ultrasonication method using F68 (Poloxamer 188) and F127 (Poloxamer 407) as stabilizers. Formulation and process variables (concentration of stabilizers and drug, power input and duration of ultrasonication) affecting th...