nutrition is an important factor that influences immunity, and nutritional deficiencies can impair resistance to infections. malnutrition is the most common cause of immunodeficiency worldwide. trace elements such as zinc, selenium, iron, and copper can influence several components of immunity. primary antibody deficiency disorders are a group of disorders characterized by an unusual susceptibi...

autism is a neurodevelopmental disorder, characterized by poor social interaction and communication impairment and repetitive behavior. autism is considered as a genetic and multifactorial disorder, with diverse risk factors involved. herein, we report a 13-year-old male with common variable immunodeficiency (cvid), who was diagnosed with autism at the age of 3 years old. as  there  are  some  ...

Immunoglobulin (Ig) A deficiency has long been recognized in patients with chromosome 18 abnormalities. We present the case of a young girl in whom a chromosome 18p deletion syndrome (46,XX,del[18][p11.1]) was associated not only with IgA deficiency, but also with an inability to make antibody to the unconjugated pneumococcal polysaccharide vaccine, Pneumovax II, indicating a concomitant specif...

Chronic Obstructive Pulmonary Disease is the third leading cause of death in the US, and is associated with periodic exacerbations, which account for the largest proportion of health care utilization, and lead to significant morbidity, mortality, and worsening lung function. A subset of patients with COPD have frequent exacerbations, occurring 2 or more times per year. Despite many intervention...

The developmental disorder Rubinstein-Taybi syndrome (RTS) is frequently complicated by recurrent respiratory infections. In many cases this is likely to be the result of microaspiration or gastro-oesophageal reflux but, in a proportion, underlying antibody deficiency is a potentially modifiable susceptibility factor for infection. Relatively subtle, specific defects of pneumococcal antibody pr...

coincidence of autoimmune diseases such as immune thrombocytopenic purpura (itp) with  immunodeficiencies has  been  reported  previously in  patients  who  suffered  from primary antibody deficiency (pad). but there is no original study on immunological profiles of itp patients to find out their probable immune deficiency. in this case-control study, itp patients’ humoral immunity was investig...

OBJECTIVES Systemic lupus erythematosus (SLE) is typically associated with hypergammaglobulinaemia but has been described in the setting of hypogammaglobulinaemia as well. The purpose of this article is to describe various cases of SLE and hypogammaglobulinaemia, review the literature and present management strategies for hypogammaglobulinaemia in SLE. METHODS We describe five patients with S...

background: primary antibody deficiency, the most common primary immunodeficiency disorder, represents a heterogeneous spectrum of conditions caused by a defect in any critical stage of b cell development and is characterized by impaired production of normal amounts of antigen-specific antibodies. objective: this retrospective study aimed at description and analysis of demographic, clinical, im...

we present the first reported case of antiphospholipid syndrome with stroke in an iranian boy (7-month-old) who had two ischemic strokes within a period of 2 months. serum anticardiolipid antibody was positive and the patient had low levels of protein s and c. this case emphasizes the importance of antiphospholipid antibody in children with unexplained ischemic stroke.