Vitamin A and its derivatives have recently reported to be implicated in synaptic plasticity. The possible effect of vitamin A and its precursor, ?-carotene, on seizure acquisition was tested in PTZ kindling model of epilepsy. Vitamin A and ?-carotene were tested for their ability to 1) suppress seizures (clonic and tonic) and lethality induced by PTZ in PTZ-kindled mice (anticonvulsant effect)...

Background and objectives: Berberis vulgaris L (Berberidaceae) is a medicinal plant that is distributed in different parts of Iran; it is grown as a wild or cultivated plant. It has different pharmacological activities such as antioxidant, anti-inflammatory, anti-arrhythmic, sedative and anti-malaria effects. In this study, the anti-seizure activity of different fracti...

Vitamin A and its derivatives have recently reported to be implicated in synaptic plasticity. The possible effect of vitamin A and its precursor, ?-carotene, on seizure acquisition was tested in PTZ kindling model of epilepsy. Vitamin A and ?-carotene were tested for their ability to 1) suppress seizures (clonic and tonic) and lethality induced by PTZ in PTZ-kindled mice (anticonvulsant effect)...

epilepsy is a neurological disease of the central nervous system. it is estimated that about 50-70 million people worldwide suffer from this chronic disorder and 20 to 30% are resistant to conventional anti-epileptic drugs. in the epilepsy therapeutic arena, there is real need for developing novel antiepileptogenesis treatments that offer a way to prevent the onset or the progression of the dis...

Epilepsy is a neurological disease of the central nervous system. It is estimated that about 50-70 million people worldwide suffer from this chronic disorder and 20 to 30% are resistant to conventional anti-epileptic drugs. In the epilepsy therapeutic arena, there is real need for developing novel antiepileptogenesis treatments that offer a way to prevent the onset or the progression of the dis...

creatine exerts beneficial effects on a variety of pathologies in which energy metabolism and oxidative stress play an etiological role. creatine supplements have shown beneficial effects on neurological disorders including parkinson's disease, huntington's disease, amyotrophic lateral sclerosis, alzheimer's disease and stroke. however, the potential benefits of creatine for pati...

a 73-year-old female patient developed a generalized tonic-clonic seizure on the 6th day after treatment with moxifloxacin 400 mg daily intravenously for appendicitis. this patient had atrial fibrillation and history of a surgery for intracerebral hemorrhage, with impaired renal function and liver function, but without history of seizures. moxifloxacin was discontinued and switched to cefuroxim...

Epileptic seizures result from abnormal brain activity and can affect motor, autonomic and sensory function; as well as, memory, cognition, behavior, or emotional state. Effective anti-epileptic drugs (AEDs) are available but have tolerability issues due to their side effects. The Malaysian herb Orthosiphon stamineus, is a traditional epilepsy remedy and possesses anti-inflammatory, anti-oxidan...

Epilepsy is the oldest nervous system disorder known to mankind and one of the most common diseases in human population. Despite extensive studies, multiple aspects of the disease and the nature of the disorder are still unclear. Currently 30-40% of the epileptic patients show resistance to all of the conventional therapeutic agents. In Iranian traditional medicine, various types of plants have...

background: despite availability and administration of numerous antiepileptic drugs (aeds) nearly 15% of childhood epilepsy cases are resistant to treatment; in traditional medicine however nigella sativa l. (black seed) has been known for its anticonvulsant effects. materials and methods: in this double-blind clinical trial conducted on children with refractory epilepsy we administered the aqu...