GDC-0339 is a novel small molecule pan-Pim kinase inhibitor that was discovered as a potential treatment of multiple myeloma. During the in vitro and in vivo metabolite profiling of GDC-0339, a metabolite was detected that had the same elemental composition as the parent but was distinct with respect to its chromatographic separation and mass spectrometric fragmentation pattern. High resolution...

A. H. BUIST,* M. MÜLLER,* E. J. GIJSBERS,* G. J. BRAKENHOFF,* T. S. SOSNOWSKI,† T. B. NORRIS† & J. SQUIER‡ *BioCentrum Amsterdam, University of Amsterdam, Department of Molecular Cytology, Kruislaan 316, 1098 SM Amsterdam, The Netherlands †Center for Ultrafast Optical Science, University of Michigan, 2200 Bonisteel Blvd, IST Building, Ann Arbor, MI 48109–2099, U.S.A. ‡Department of Electrical a...

Serena Andreotti 1,2, Elisa Franzoni 1,2,* ID , Micaela Degli Esposti 1,2 ID and Paola Fabbri 1,2 1 Department of Civil, Chemical, Environmental and Materials Engineering, University of Bologna, 40131 Bologna, Italy; [email protected] (S.A.); [email protected] (M.D.E.); [email protected] (P.F.) 2 Consorzio Interuniversitario di Scienza e Tecnologia dei Materiali (INSTM), 50...

Christopher T. Rota*, Robert J. Fletcher Jr, Robert M. Dorazio and Matthew G. Betts Wildlife Ecology and Conservation, University of Florida, PO Box 110430, Gainesville, FL 32611-0430, USA; Department of Statistics, US Geological Survey and University of Florida, Gainesville, FL 32611-0339, USA; and Department of Forest Ecosystems and Society, Oregon State University, 216 Richardson Hall, Corva...

*Biostatistics Branch, National Institute of Environmental Health Sciences, PO Box 12233, Research Triangle Park, North Carolina 27709; †Department of Mathematics and Statistics, Miami University, Oxford, Ohio 45056-1641; ‡Division of Biometry and Risk Assessment, National Center for Toxicological Research, Jefferson, Arkansas 72079; §Analytical Sciences, Inc., Durham, North Carolina 27713; and...

Sheila M. Reynolds, Mary C. Christman, J. Albert C. Uy, Gail L. Patricelli, Michael J. Braun, and Gerald Borgia Behavior, Ecology, Evolution, and Systematics Program, Biology/Psychology Building, University of Maryland, College Park, MD 20742, USA, Department of Vertebrate Zoology, National Museum of Natural History, Smithsonian Institution, 4210 Silver Hill Road, Suitland, MD 20746, USA, Depar...

7 Short title: Landscape-based geostatistics 8 9 Olaf P. Jensen, Mary C. Christman, and Thomas J. Miller 10 11 12 University of Maryland Center for Environmental Science Chesapeake Biological 13 Laboratory, P.O. Box 38, 1 Williams St., Solomons, MD 20688 14 15 Current address: University of Wisconsin Center for Limnology, 680 N Park St., 16 Madison, WI 53706, USA 17 18 Dept. Animal and Avian Sc...