background nonalcoholic steatohepatitis (nash) is a common liver disease that can progress to cirrhosis or hepatocellular carcinoma. it is estimated that up to 3% of the iranian population have this condition. although the pathogenesis of nash is incompletely understood, there is significant evidence pointing to the importance of insulin resistance. metformin is an oral hypoglycemic agent known...

IMPORTANCE Nonalcoholic fatty liver disease and its subtype nonalcoholic steatohepatitis affect approximately 30% and 5%, respectively, of the US population. In patients with nonalcoholic steatohepatitis, half of deaths are due to cardiovascular disease and malignancy, yet awareness of this remains low. Cirrhosis, the third leading cause of death in patients with nonalcoholic fatty liver diseas...

non-alcoholic steatohepatitis (nash) is a disease of unknown origin characterized histologically by alcoholic-like liver injury in the absence in the absence of significant alcohol intake. this study was conducted to assess the clinical and pathological features of nash patients in iran. patients with elevated liver transaminases, negative serologic markers of viral or autoimmune hepatitis and ...

Nonalcoholic fatty liver disease (NAFLD) is an umbrella term for a range of liver conditions affecting people who drink little to no alcohol. As the name implies, the main characteristic of nonalcoholic fatty liver disease is too much fat stored in liver cells. Nonalcoholic steatohepatitis, a potentially serious form of the disease, is marked by liver inflammation, which may progress to scarrin...

fatty liver disease (fld) is the most prevalent form of liver disease worldwide. overnutrition can induce nonalcoholic fatty liver disease (nafld), a spectrum of conditions ranging from simple steatosis [or nonalcoholic fatty liver (nafl)] to nonalcoholic steatohepatitis and cirrhosis. some of the epidemiological and pathological studies have also suggested an association between the presence o...

CONTEXT Limited clinical data suggest Helicobacter pylori (Hp) infection may contribute to nonalcoholic fatty liver disease (NAFLD) pathogenesis. OBJECTIVES The effect of Hp eradication on hepatic steatosis (magnetic resonance imaging), nonalcoholic fatty liver disease fibrosis score and HSENSI (Homocysteine, serum glutamic oxaloacetic transaminase, Erythrocyte sedimentation rate, nonalcoholi...

INTRODUCTION Leptin has been implicated in the pathogenesis of nonalcoholic steatohepatitis. It has also been suggested that adiponectin plays an important role in the transition from fatty liver disease to nonalcoholic steatohepatitis. OBJECTIVE To evaluate whether leptin and adiponectin levels are related to the degree of necroinflammatory activity and fibrosis in patients with nonalcoholic...

In recent years, metabolomics has attracted great scientific attention. The metabolomics methodology might permit a view into transitional phases between healthy liver and nonalcoholic steatohepatitis. Metabolomics can help to analyze the metabolic alterations that play a main role in the progression of nonalcoholic steatohepatitis. Lipid, glucose, amino acid, and bile acid metabolism should be...

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