Introduction Alpha-lipoic acid (ALA – also known as thioctic acid) was discovered in 1951 as a molecule that assists in acyl-group transfer and as a coenzyme in the Krebs cycle. In the 1980s, the scientific community realized alpha-lipoic acid is a powerful antioxidant. Several qualities distinguish alpha-lipoic acid from other antioxidants: ALA can be synthesized by animals and humans;1 it neu...

Alpha-lipoic acid (ALA), a naturally occuring compound and a radical scavenger was shown to enhance glucose transport and utilization in different experimental and animal models. Clinical studies described an increase of insulin sensitivity after acute and short-term (10 d) parenteral administration of ALA. The effects of a 4-week oral treatment with alpha-lipoic acid were evaluated in a placeb...

background: cryopreservation of pre-antral follicles is a hopeful technique to preserve female fertility. the aim of the present study was to evaluate reactive oxygen species (ros) and total antioxidant capacity (tac) levels of mouse vitrified pre-antral follicles in the presence of alpha lipoic acid (ala). methods: isolated pre-antral follicles (140–150 µm in diameter) were divided into vitrif...

The increase in the number and life expectancy of patients with diabetes mellitus (DM) worldwide determines high prevalence late complications diabetes, including diabetic polyneuropathy (DPN), most common type polyneuropathy. Oxidative stress is considered main reason for cellular pathology development mellitus, which use antioxidants DPN treatment. Alpha-lipoic acid (ALA), a natural fat-solub...

The aim of this study was to estimate the effects of oral supplementation of alpha-lipoic acid (ALA) on contrast sensitivity (CS) in patients with type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM). The study included 12 patients with T1DM aged 43±12 years, 48 patients with T2DM aged 59±10 years, and 20 control subjects aged 33±8 years. Patients from each studied group, includi...

The aim of this study was to compare the indices of glutathione antioxidant system and oxidative damage level in resistance trained and untrained subjects and to assess the antioxidant action of alpha-lipoic acid in trained men exposed to muscle-damaging exercise. Thirteen trained and twenty untrained men (NT) participated in the comparative study. Then trained men were randomly assigned to T(C...

AIM Alpha-lipoic acid (ALA) has been used as an antioxidant. The aim of this study was to investigate the effect of alpha-lipoic acid on cholecystokinin (CCK)-octapeptide induced acute pancreatitis in rats. METHODS ALA at 1 mg/kg was intra-peritoneally injected, followed by 75 microg/kg CCK-octapeptide injected thrice subcutaneously after 1, 3, and 5 h. This whole procedure was repeated for 5...

The present study aimed to evaluate the effect of chronic co-exposure to chlorpyrifos (CPF) and deltamethrin (DLT) on erythrocyte osmotic fragility, lipid peroxidation and the ameliorative effect of alpha-lipoic acid (ALA) on erythrocyte fragility. Thirty-six male Wistar rats divided into six groups of six rats each were used for the study. Groups I (S/oil) and II (ALA) were given soya oil (2 m...