Alpha-synuclein is the major component of Lewy bodies, insoluble protein aggregates, found in patients with Parkinson’s disease, diffuse Lewy body disease, and the Lewy body variant of Alzheimer’s disease. Alpha-synuclein has been found within Lewy bodies to contain many different modifications, including nitration, phosphorylation, ubiquitination, and truncation. C-terminally truncated forms o...

Parkinson disease (PD) is caused by several pathogenic mutations in genes such as alphasynuclein (SNCA; MIM#163890), Leucine-rich repeat kinase 2 (LRRK2; MIM#609007), PARKIN (parkin; MIM#602544), PTEN-induced kinase 1 (PINK1; MIM#608309), and DJ-1 (MIM#602533) (Farrer, 2006). The alpha-synuclein protein is also a major component of Lewy bodies (LB), the pathologic substrate that is observed in ...

It is both ironic and remarkable that now, almost 200 years later, the question of interaction between the gut and the brain in Parkinson’s disease (PD) has resurfaced to become the subject of a veritable tsunami of fascinating and tremendously important research that has potential ramifications not only for understanding the pathophysiology of PD but also for its treatment and even its diagnos...

The progression of many human neurodegenerative disorders is associated with an accumulation of alpha-synuclein. Alphasynuclein belongs to the homologous synuclein family, which includes beta-synuclein. It has been proposed that betasynuclein may be a natural regulator of alpha-synuclein. Therefore controlling beta-synuclein expression may control the accumulation of alpha-synuclein and ultimat...

To analyze the protective effect and mechanism of beta-asarone from Acorus tatarinowii on neuron injury in rats with Parkinson's disease. Thirty five male Sprague Dawley were randomly selected to establish rat model The divided into 5 groups as sham operation group, low dose medium group high betaasarone 7 each group. Rats injected same amount normal saline, while middle 10 mg/kg, 20 mg/kg 40 r...

Cumulative evidence now suggests that the abnormal aggregation of the neuronal protein alpha-synuclein is critically involved in the pathogenesis of synucleinopathies, of which Parkinson’s disease (PD) is the most prevalent. Development of neuropathology appears to be linked to events that accelerate the rate of aggregation of alphasynuclein from monomers, via soluble oligomeric intermediates, ...

In the prescriptions of an endocrinologist to patients with diabetes mellitus, glucagon-like peptide agonists, belonging group that affects incretin system body, have recently been increasingly appearing. addition pronounced hypoglycemic effect and high safety, these drugs also many pleiotropic properties due presence receptors in vascular endothelium, kidneys, heart nervous tissue. The purpose...

1366-Pos Board B96 Single Molecule FRET Characterization of Oligomers from AlphaSynuclein Early Onset Parkinson’s Disease Mutants Laura Tosatto1,2, MathewH. Horrocks1, Cremades Nunilo1, Tim Guilliams1, Mauro Dalla Serra2, David Klenerman1. Chemistry, University of Cambridge, Cambridge, United Kingdom, Istituto di Biofisica, CNR, Trento, Italy. Parkinson’s disease is the most diffused neurodegen...

Citation: Jia F, Song N, Wang W, Du X, Chi Y and Jiang H (2018) High Dietary Iron Supplement Induces the Nigrostriatal Dopaminergic Neurons Lesion in Transgenic Mice Expressing Mutant A53T Human Alpha-Synuclein. Front. Aging Neurosci. 10:97. doi: 10.3389/fnagi.2018.00097 Both alpha-synuclein aggregation and iron deposits are neuropathological hallmarks of Parkinson’s disease (PD). We are partic...