ammonia is a toxic material for mammalians. it is detoxificated and converted to urea in the urea cycle in liver. each defect in the urea cycle cause increase in blood ammonia level. ornithine transcarbamylase enzyme (otc) is the second enzyme in the urea cycle that exists in mitochondria. otc deficiency is the most common hereditary disorder in the urea cycle. in this study, 45 hyper ammonia p...

background: margarine contain trans fatty acids as major sources of dietary free radicals, and oxidative stress. effect of oral administration of margarine on hepatic enzyme was investigated in wistar rats. methods: thirty six (36) adult wistar rats were uniformly divided into three groups of control , margarine 15% and 20%, twelve rats in each groups (6males & 6 females). margarine was added t...

backgrounds normal or elevated values of serum alanine aminotransferase level (alt) vary in different studies mostly related to characteristics of reference population including age, gender, body mass index, nonalcoholic fatty liver disease (nafld), and metabolic syndrome prevalence. objectives to measure upper normal limit (unl) for serum alt in an apparently healthy iranian old population (wh...