Background: Muscle invasive bladder cancer (BC) has a mortality rate of 50% in 5 years, despite the aggressive treatments currently used. The diagnosis of latent tumor cells in histologically normal lymph nodes (LN) may have prognostic value and may explain the tumoral recurrence in BC. Methods: Here we evaluated the use of the AE1AE3 cytokeratin marker through immunohistochemical examination o...

Results Of the 22 studied cases, the majority had > 3 cm neoplasms (15/19, 78.95%) and lymph node metastases (16/16, 100%), but only two cases (2/9, 22.2%) had distant metastases. The IMPCs were classified as either pure (15/22, 68.18%) or mixed (7/22, 31.82%) types. A predominance of moderate histological grade (16 grade II) tumours was observed and the average overall survival was 120 days. P...

Uterine leiomyosarcoma (ULMS) is an uncommon malignancy that accounts for one-third of uterine sarcomas and represents 1% of all uterine malignancies, with an incidence averaging 0.5-1/100,000/year. The prognosis is poor due to its intrinsic aggressiveness and its characteristic high metastatic potential with reported distant metastatic spread in lung, abdomen, soft tissue, and brain. We presen...

The alveolar adenoma of the lung is a rare benign tumor characterized by a proliferation of both the alveolar epithelial cells and the mesenchymal septal cells. Immunohistochemically, the epithelial cells stain for cytokeratin (CK) AE1AE3, CK7, thyroid transcription factor 1 (TTF1), and surfactant apoprotein confirming the derivation by the type 2 pneumocytes. The stromal cells are negative for...

ABSTRACT: This is a case of medulloepithelioma in 14-year-old mixed breed gelding horse, presenting large abnormal mass tissue involving the entire extension right eye. Ophthalmic examination showed deformation and swelling The animal signs pain on palpation organ, but specific systems did not reveal any other changes. Due to apparently neoplastic discomfort experienced by animal, transpalpebra...

Cystic tumours of the atrioventricular node (sometimes called ‘‘benign mesotheliomas of the atrioventricular node’’) are rare lesions associated with sudden cardiac death. 2 A recent case provided several informative points regarding the nature of this lesion and best practice methodology within the coroner’s necropsy. A 31 year old man, training for a marathon, collapsed and died suddenly with...

BACKGROUND Breast cancer is the most common malignant neoplasm in the female population. However, stomach is a rare site for metastasis, and can show up many years after initial diagnosis and treatment of the primary tumor. AIM Analyze a case series of this tumor and propose measures that can diagnose it with more precocity. METHODS Were analyzed 12 patients with secondary gastric tumors. I...

Metastasis to the thyroid gland is very rare. It is very important to differentiate metastasis to thyroid from primary thyroid malignancy from the treatment point of view. A 48-years-old lady presented with weakness of lower limbs and backache since one and half months. External examinations reveal diffuse, nodular goitre. A fine-needle aspiration (FNA) of the thyroid nodule showed malignant ep...