Five young adult Rhesus monkeys were included in this study. The weight of the animals ranged from 3.4 to 4.0 kg, with a mean of 3.6 kg. Each animal was restrained and anesthetized with ketamine HC1 at 25 mg/kg IM. An intravenous fluid of 5% dextrose and water with 1/4 normal saline was initiated and profused at a maintenance rate. Each monkey received intranasal midazolam (VersedTM, Roche Phar...

The pharmacokinetics of trimethoprim-sulfamethoxazole were studied in 12 healthy adult subjects receiving trimethoprim at 20 mg/kg of body weight per day and sulfamethoxazole at 100 mg/kg/day, which is the conventional dose for treating Pneumocystis carinii pneumonia (PCP). Daily doses were evenly divided and orally administered every 6 h for 3 days. Trimethoprim, sulfamethoxazole, and N4-acety...

SUBJECTS, MATERIALS, AND METHODS DRUG ADMINISTRATION HALLUCINOGEN RATING SCALE STATISTICS RESULTS 0.4-MG/KG DOSE PERCEPTION SOMAESTHESIA AFFECT COGNITION VOLITION INTENSITY 0.2-MG/KG DOSE 0.1-MG/KG DOSE 0.05-MG/KG DOSE HALLUCINOGEN RATING SCALE TECHNICAL COMMENT ON ASSESSMENT OF SUBJECTIVE EFFECTS COMMENT REFERENCES

synthetic lhrha or its superactive analogues stimulate gth release. it shows an overlap in the biological activity of lhrha and gnrh in many teleost species. the aim of the present study was to investigate the effects of lhrha2, metoclopramide and chlorpromazine on hpg axis and plasma levels of ght ii. luteinizing hormone releasing hormone analogue 2 (lhrha2) (3 mg/kg) with dopamine antagonis’s...