This deliverable summarizes the results and experiences of working group A3 on establishing personalization strategies in the Semantic Web by presenting best practices for personal information systems in the Semantic Web. It builds on the work reported in Deliverables A3-D1 to A3-D9 which have investigated on necessary theoretical foundations (Deliverables A3-D1, A3D4 and A3-D7), Prototypes and...

Little is known about the repertoire of MAGE-A3 CD4(+) T-cell epitopes recognized in vivo by neoplastic patients and how antigen processing influences epitope formation. Here, we first show that MAGE-A3-specific CD4(+) T cells are present in the blood of advanced melanoma patients. MAGE-A3(111-125), MAGE-A3(191-205), and MAGE-A3(281-300) were recognized by 7, 6, and 5 of the 11 patients tested,...

Done all A–1 Determine, with proof, the number of ordered triples (A1, A2, A3) of sets which have the property that (i) A1 ∪A2 ∪A3 = {1, 2, 3, 4, 5, 6, 7, 8, 9, 10}, and (ii) A1 ∩A2 ∩A3 = ∅. Express your answer in the form 2357, where a, b, c, d are nonnegative integers. Solution: For each integer i from 1 to 10 you must put i in one of 6 sets: A1 ∩ A2 ∩ A3 or A1 ∩ A2 ∩ A3 or A1 ∩ A2 ∩ A3 or A1...

In this paper we show that del Pezzo surfaces of degree 1 with Du Val singular points of type A4, A4 + A4, A4 + A3, A4 + 2A1, A4 + A1, A3 + 4A1, A3 + 3A1, 2A3 + 2A1, A3 + 2A1, A3 + A1, 2A3, A3, admit a Kähler-Einstein metric. Moreover we are going to compute global log canonical thresholds of del Pezzo surfaces of degree 1 with Du Val singularities, and of del Pezzo surfaces of Picard group Z w...

Urea has a critical role in urinary concentration. Mice lacking the inner medullary collecting duct (IMCD) urea transporter A1 (UT-A1) and urea transporter A3 (UT-A3) have very low levels of urea permeability and are unable to concentrate urine. To investigate the role of UT-A1 in the concentration of urine, we transgenically expressed UT-A1 in knockout mice lacking UT-A1 and UT-A3 using a cons...

Adenosine plays an important role in regulation of renal microcirculation. All receptors of adenosine, A1, A2A, A2B, and A3, have been found in the kidney. However, little is known about the location and function of the A3 receptor in the kidney. The present study determined the expression and role of A3 receptors in mediating the afferent arteriole (Af-Art) response and studied the interaction...

Vaccination with cancer/testis Ag MAGE-A3 in the form of recombinant protein often induces specific humoral and cellular immune responses. Although Ag-specific CD4+ T cells following vaccination are detectable by cytokine production after a single in vitro stimulation, their detection before vaccination is difficult because of low frequency. In this study, we have applied a sensitive method usi...

Early detection of resistance to platinum-based therapy is critical for improving the treatment of ovarian cancers. We have previously found that increased expression of annexin A3 is a mechanism for platinum resistance in ovarian cancer cells. Here we demonstrate that annexin A3 can be detected in the culture medium of ovarian cancer cells, particularly these cells that express high levels of ...