The effect of intracerebroventricular (i.c.v.) injection of Aβ25-35 and/or intraperitoneal (i.p.) application of the L-type calcium channel (VDCC) blockers verapamil or diltiazem were examined in vivo. In order to by-pass possible systemic actions of these agents their effects on LTP in the CA1 region of the in vitro hippocampal slice preparation were also examined. Application of Aβ25-35 (10nm...