A novel, simple and economic reverse phase high performance liquid chromatography (RP-HPLC) method has been developed for the estimation of zolpidem tartrate in bulk and tablet dosage form with greater precision and accuracy. Separation was achieved on C18 column (250X4.6mm i.d.,5μm) in isocratic mode using methanol and acetonitrile in the ratio 50:50 (v/v) as mobile phase, pumped in to the col...

A simple, sensitive, rapid, accurate and precise spectrophotometric method has been developed for the estimation of Zolpidem tartrate in bulk and pharmaceutical dosage forms. Zolpidem tartrate shows maximum absorbance at 238.5 nm with molar absorptivity of 4.4648×10lit/mol/cm. Beer’s law was obeyed in the concentration range of 2-16 μg/ml. The limit of detection and limit of quantification were...

A novel, simple and economic reverse phase high performance liquid chromatography (RP-HPLC) Stability indicating method has been developed for the estimation of zolpidem tartrate in bulk and tablet dosage form with greater precision and accuracy. Separation was achieved on C18 column (250X4.6mm i.d.,5μm) in isocratic mode using methanol and acetonitrile in the ratio 50:50 (v/v) as mobile phase,...

OBJECTIVE Gabapentin is being investigated as a potential treatment for occasional disturbed sleep. This study assessed the pharmacokinetics and tolerability of gabapentin 500 mg and the commonly prescribed sedative/hypnotic zolpidem tartrate 10 mg, administered separately and in combination. METHODS Forty healthy participants (19 male, 21 female) were randomized into this three-period crosso...

The objective of this study was to evaluate the difference in the pharmacokinetics of zolpidem tatrate in subjects from five Chinese ethnicities (Han, Mongolian, Uigur, Korean and Hui). Healthy subjects (10 Hans, 10 Mongolians, 10 Uigurs, 10 Koreans and 9 Huis) were recruited and each received a 10 mg tablet-dose of zolpidem tatrate. A total of 12 plasma samples were collected over a 12 h perio...

The aim of the current study was to develop a simple, precise, and accurate capillary zone electrophoresis method for the determination of zolpidem tartrate in tablet dosage form. Separation was conducted in normal polarity mode at 25°C, 22 kV, using hydrodynamic injection for 10 s. Separation was achieved using a background electrolyte of 20 mM disodium hydrogen phosphate adjusted with phospho...

Three simple, precise and economical UV spectrophotometric methods have been developed for the estimation of Zolpidem tartrate in bulk and tablet formulations. Zolpidem tartrate has absorbance maxima at 293 nm in zero order spectrum method (Method A ) First order derivative spectra of drug, showed λ maxima = 305 nm and λ minima = 280 nm and amplitude difference was measured for the respective c...

Zolpidem, an imidazoline nonbenzodiazepine sedative drug, is used widely. Initial reports showed minimal abuse potential. However, multiple reports have appeared of dose escalation and abuse. Subjective effects of high-dose zolpidem are not known. In light of accumulating evidence of abuse potential, we hereby report a case of high-dose dependence and a review of relevant literature. A 33-year-...