نتایج جستجو برای: ZFX

تعداد نتایج: 164  

2016
Xuebing Yan Zezhi Shan Leilei Yan Qingchao Zhu Liguo Liu Bing Xu Sihong Liu Zhiming Jin Yuping Gao

Zinc-finger protein X-linked (ZFX) was recently identified as a novel oncoprotein in several human malignancies. In this study, we examined the correlation between ZFX expression and the clinical characteristics of stage II/III CRC patients, as well as the molecular mechanism by which ZFX apparently contributes to CRC tumor progression. Using immunohistochemistry, we detected expression of ZFX ...

2013
Rui Jiang Zhong-li Gao Mei Sun Xing-yi Zhang Jin-cheng Wang Han Wu

OBJECTIVE To investigate the role of Zinc finger X-chromosomal protein (ZFX) in oncogenesis of Osteosarcoma tumor. METHODS Here, we first conducted an expression analysis of ZFX in Osteosarcoma cell lines. Then, we constructed ZFX-specific small interfering RNA (siRNA)-lentiviral vector that is capable of effectively inhibiting the expression of ZFX gene in human Osteosarcoma Saos-2 cells, an...

2015
Changying Li Hongjie Li Ting Zhang Jianmin Li Fuling Ma Mei Li Zhifang Sui Jiwu Chang

BACKGROUND This study was designed to assay the expression of zinc finger protein X-linked (ZFX) in renal cell carcinoma (RCC) tissues and evaluate the correlation between ZFX expression and prognosis of RCC patients. MATERIAL AND METHODS The expressions of ZFX mRNA in 53 RCC tissues and 51 normal tissues were determined by quantitative real-time polymerase chain reaction (qRT-PCR). Immunohis...

2017
Chao Wang Si‐yuan Fu Ming‐da Wang Wen‐bo Yu Qin‐shu Cui Hong‐ru Wang Hai Huang Wei Dong Wei‐wei Zhang Peng‐peng Li Chuan Lin Ze‐ya Pan Yuan Yang Meng‐chao Wu Wei‐ping Zhou

Zinc finger protein X-linked (ZFX) is frequently upregulated in multiple human malignancies and also plays a critical role in the maintenance of self-renewal in embryonic stem cells. However, the role of ZFX in liver cancer stem cells (CSCs) remains obscure. We observed that the elevated expression of both ZFX and epithelial cell adhesion molecule (EpCAM) was associated with aggressive clinicop...

2016
Shuhong Zhang Ronghua Shu Meng Yue

BACKGROUND X-chromosome-coupled zinc finger protein (ZFX) in the Zfy protein family is abundantly expressed in both embryonic and hematopoietic stem cells (HSCs). ZFX exist in various tumor cells and is correlated with proliferation and survival of tumor cells. As a malignant tumor with high invasiveness, hepatocellular carcinoma (HCC) may present resistance against chemotherapy and features of...

Journal: :Cell 2007
Jose M. Galan-Caridad Sivan Harel Teresita L. Arenzana Z. Esther Hou Fiona K. Doetsch Leonid A. Mirny Boris Reizis

Stem cells (SC) exhibit a unique capacity for self-renewal in an undifferentiated state. It is unclear whether the self-renewal of pluripotent embryonic SC (ESC) and of tissue-specific adult SC such as hematopoietic SC (HSC) is controlled by common mechanisms. The deletion of transcription factor Zfx impaired the self-renewal but not the differentiation capacity of murine ESC; conversely, Zfx o...

Journal: :Molecular and cellular biology 1990
G Mardon S W Luoh E M Simpson G Gill L G Brown D C Page

The Zfy gene is located on the Y chromosome of placental mammals and encodes a zinc finger protein which may serve as the primary sex-determining signal. A related gene, Zfx, is similarly conserved on the X chromosome. Unlike that in most mammals, the mouse genome contains four homologous zinc finger loci: Zfy-1, Zfy-2, Zfx, and Zfa (on an autosome). We report that, in contrast to the mouse Zfy...

Journal: :Cell 1989
A Schneider-Gädicke P Beer-Romero L G Brown R Nussbaum D C Page

The ZFX gene on the human X chromosome is structurally similar to the ZFY gene, which may constitute the sex-determining signal on the human Y chromosome. ZFY and ZFX diverged from a common ancestral gene, as evidenced by similarities in their intron/exon organization and exon DNA sequences. The carboxy-terminal exons of ZFY and ZFX both encode 13 zinc fingers; 383 of 393 amino acid residues ar...

2011
Youxin Zhou Zuopeng Su Yulun Huang Ting Sun Sansong Chen Tingfeng Wu Guilin Chen Xueshun Xie Bin Li Ziwei Du

BACKGROUND Zfx is a zinc finger protein of the Zfy family, whose members are highly conserved in vertebrates. Zfx is a shared transcriptional regulator of both embryonic stem cells (ESC) and hematopoietic stem cells (HSC), which suggests a common genetic basis of self-renewal in embryonic and adult stem cells. The level of Zfx expression correlates with aggressiveness and severity in many cance...

Journal: :Cell reports 2014
Stuart P Weisberg Matthew R Smith-Raska Jose M Esquilin Ji Zhang Teresita L Arenzana Colleen M Lau Michael Churchill Haiyan Pan Apostolos Klinakis Jack E Dixon Leonid A Mirny Siddhartha Mukherjee Boris Reizis

Tumor-propagating cells in acute leukemia maintain a stem/progenitor-like immature phenotype and proliferative capacity. Acute myeloid leukemia (AML) and acute T-lymphoblastic leukemia (T-ALL) originate from different lineages through distinct oncogenic events such as MLL fusions and Notch signaling, respectively. We found that Zfx, a transcription factor that controls hematopoietic stem cell s...

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