175Yb is a radionuclide that can be generated by neutron capture on 174Yb and whose decay properties make it useful for developing therapeutic radiopharmaceuticals. As happens with many of the emerging radionuclides medical uses in recent years, its nuclear data were determined decades ago are not thoroughly documented nor accurate enough metrological purposes. The last reference half-life valu...

OBJECTIVE Optimized production and quality control of ytterbium-175 (Yb-175) labeled pamidronate and alendronate complexes as efficient agents for bone pain palliation has been presented. METHODS Yb-175 labeled pamidronate and alendronate (175Yb-PMD and 175Yb-ALN) complexes were prepared successfully at optimized conditions with acceptable radiochemical purity, stability and significant hydro...

      Bone is the third most common site of metastatic disease. Bone pain is the major source of morbidity associated bone metastasis. Bone-seeking radiopharma- ceuticals have been applied for many years. The ability to simultaneously treat multiple sites of disease with a more probable therapeutic effect in earlier phases of metastatic disease is one of the advantages of radiopharmaceuticals. ...

Introduction: Bleomycins are DNA-binding biomolecules, which can be used as targeted therapy carriers when labeled with particle-emitters such as Yb-175. In this work the development of Yb-175 bleomycin (175Yb-BLM) has been reported. Methods: Yb-175 chloride was obtained by thermal neutron irradiation (3 × 1013 n.cm-2.s-1) of natural Yb2O<...

introduction: bleomycins are dna-binding biomolecules, which can be used as targeted therapy carriers when labeled with particle-emitters such as yb-175. in this work the development of yb-175 bleomycin (175yb-blm) has been reported. methods: yb-175 chloride was obtained by thermal neutron irradiation (3 × 1013 n.cm-2.s-1) of natural yb2o3 samples at various neutron fluxes and irradiation time...

Introduction: Bleomycins are DNA-binding biomolecules, which can be used as targeted therapy carriers when labeled with particle-emitters such as Yb-175. In this work the development of Yb-175 bleomycin (Yb-BLM) has been reported. Methods: Yb-175 chloride was obtained by thermal neutron irradiation (3 × 10 n.cm.s) of natural Yb2O3 samples at various neutron fluxes and irradiation times. The rad...

Introduction: Nano radio-pharmaceutical therapy (NRPT) is a new method for solid tumor therapy. The treatment uses a radioactive form of radionuclide encapsulated in the poly amido amine dendrimers. The poly (amidoamine) (PAMAM) dendrimers have attracted attentions for cancer treatment by their characteristics of targeted drug carriers, delivery agents, and imaging agents in hu...

An ytterbium-doped photonic bandgap fiber amplifier operating at the long wavelength edge of the ytterbium gain band is investigated for high power amplification. The spectral filtering effect of the photonic bandgap efficiently suppresses amplified spontaneous emission at the conventional ytterbium gain wavelengths and thus enables high power amplification at 1178 nm. A record output power of ...

The internal stresses of plasma-sprayed multilayer ytterbium disilicate environmental barrier coatings were measured using microfocused high-energy X-rays in a transmission geometry. Stresses were measured for as-sprayed and ex-situ heat-treated ytterbium disilicate topcoats at room temperature and during in-situ heating and cooling experiments. In-situ loading experiments were also performed o...

Novel biodegradable Poly (L-lactic acid) (PLLA) microspheres containing ytterbium were designed for intra-tumoral radiotherapy, especially for radioembolization. 175Yb possess both therapeutic beta and diagnostic gamma radiations. In this work, process to make ready radiomicrospheres 175Yb(acac)3-loaded PLLA for more consideration has been investigated. The radiomicrospheres were prepared with ...