نتایج جستجو برای: Y-maze

تعداد نتایج: 504064  

Journal: :iranian biomedical journal 0
مهرداد روغنی mehrdad roghani محمدتقی جقتایی mohammad taghi joghataie محمدرضا جلالی mohammad reza jalili توراندخت بلوچ نژاد مجرد tourandokht baluchnejadmojarad

diabetes mellitus is accompanied with disturbances in learning, memory, and cognitive skills in the human society and experimental animals. therefore, this research study was conducted to evaluate time-dependent changes in passive avoidance and y-maze performance in male diabetic rats. for this purpose, male wistar rats were randomly divided into control and diabetic groups. for induction of di...

Mehrdad Roghani, Mohammad Reza Jalili, Mohammad Taghi Joghataie, Tourandokht Baluchnejadmojarad,

Diabetes mellitus is accompanied with disturbances in learning, memory, and cognitive skills in the human society and experimental animals. Therefore, this research study was conducted to evaluate time-dependent changes in passive avoidance and Y-maze performance in male diabetic rats. For this purpose, male Wistar rats were randomly divided into control and diabetic groups. For induction of di...

Journal: :acta medica iranica 0
vahid nikoui experimental medicine research center, tehran university of medical sciences, tehran, iran. and razi drug research center, iran university of medical sciences, tehran, iran. mehrak javadi-paydar department of pharmacology, school of medicine, tehran university of medical sciences, tehran, iran. mahtab salehi department of pharmacology, school of medicine, tehran university of medical sciences, tehran, iran. selda behestani department of pharmacology, school of medicine, tehran university of medical sciences, tehran, iran. ahmad reza dehpour experimental medicine research center, tehran university of medical sciences, tehran, iran. and department of pharmacology, school of medicine, tehran university of medical sciences, tehran, iran.

lithium is a drug used for the treatment of bipolar disorder. it has several mechanisms of action, and recently it is shown that lithium can antagonize the 5-ht1b/1d serotonin receptors. sumatriptan is a 5-ht1b/1d receptor agonist used for the treatment of cluster headaches and migraine which might cause memory impairment as a potential side effect. in this study, effects of lithium on sumatrip...

2011
A. Sathish Kumar P. Amudha Satheesh Kannan

The present work is to evaluate the anxiolytic activity of a hydroalcoholic extract of Tephrosia purpuria (L) Pers (HAETP) in mice using the elevated plus-maze (EPM), elevated zero-maze (EZM), Y-maze and hole-board models. Furthermore, the anxiolytic effects of HAETP were compared to a known active anxiolytic drug diazepam. The extract, administered orally, in two different doses of HAETP 200 m...

Journal: :Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2005
Megumi Mabuchi Michiaki Imamura Naoki Kubo Koichi Morita Kazuyuki Noriyasu Takahiro Tsukamoto Keisyu Yasuda Nagara Tamaki

UNLABELLED We evaluated serial changes in cardiac sympathetic nerve distribution using 123I-metaiodobenzylguanidine (123I-MIBG) after the Maze procedure. The Maze procedure, in which multiple incisions are made in the atrium, has been concomitantly performed with mitral valve (MV) surgery in an attempt to eliminate atrial fibrillation (AF). Although attenuation of the sinoatrial node response t...

Journal: :Brain research bulletin 1991
S L Biggan R J Beninger J Cockhill K Jhamandas R J Boegman

Some authors have reported that quisqualic acid lesions of the nucleus basalis magnocellularis (NBM), although producing large cortical cholinergic losses, have little effect on memory. The purpose of the present study was to investigate the effects of quisqualic acid lesions of the NBM on working and reference memory in a double Y-maze. Each trial started with placement into one of the two end...

Journal: :journal of basic and clinical pathophysiology 2014
tourandokht baluchnejadmojarad nida jamali-raeufy mehrdad roghani fahimeh zavvary samira ramazi

background and objective: based on the effect of chronic metabolic diseases including diabetes mellitus on the learning and memory, this study was designed to assess the usefulness of administration of salvialonic acid b on lessening of learning and memory deficits in streptozotocin (stz)-diabetic rats. materials and methods: male wistar rats were allocated into control, salvialonic acid b-trea...

2016
Andrea Cabrera-Pastor Michele Malaguarnera Lucas Taoro-Gonzalez Marta Llansola Vicente Felipo

It has been proposed that extracellular cGMP modulates the ability to learn a Y maze task, but the underlying mechanisms remained unknown. Here we show that extracellular cGMP, at physiological concentrations, modulates learning in the Y maze in a biphasic way by modulating the glutamate-nitric oxide-cGMP pathway in cerebellum. Extracellular cGMP reduces glycine receptors activation inducing a ...

2010
AVIJIT CHAKRABORTY P. AMUDHA SURJIT SINGH

The present study was undertaken to evaluate the anxiolytic activity of methanolic extract of Sapindus mukorossi Gaertn.(Sapindaceae). The anxiolytic activity was evaluated by Elevated plus maze, Y-maze, Hole-board, Actophotometer, and Marble-burying behavior models. The efficacy of the extract (200 and 400 mg/kg) was compared with the standard anxiolytic drugs Diazepam (2 mg/kg) and Fluoxetine...

Journal: :basic and clinical neuroscience 0
tourandokht baluchnejadmojarad mehrdad roghani narges karimi mitra kamran

introduction: alzheimer’s disease (ad) is a enfeeble neurodegenerative disorder characterized by increased β-amyloid (aβ) deposition and neuronal dysfunction leading to impaired learning and recall. among proposed risk factors, impaired cholinergic transmission is a main cause for incidence of disease. methods: in the present study, effects of the intracerebroventricularly administration of an ...

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