Reports from active drug users state that xylazine, the veterinary tranquilliser, has been increasing in illicit supply Philadelphia. To describe trends and characteristics of unintentional deaths heroin and/or fentanyl overdose with xylazine detections occurring Philadelphia, Pennsylvania, Philadelphia Department Public Health analysed data on Medical Examiner’s Office over a 10-year period (2...

To test the hypothesis that epidural administration of lidocaine, xylazine or xylazine plus hyaluronidase provides reduced pain and stress during electroejaculation in bulls, eight 30-month-old Nellore bulls received saline solution (control), 2% lidocaine, 2% xylazine or 2% xylazine plus hyaluronidase injected into the first intercoccygeal (Co1-Co2) epidural space in randomized order. Heart ra...

Xylazine was given in six clinical cases @ 0.03 mg/kg body weight by intramuscular route, 15 minutes before the actual surgical intervention. The local anaesthetic, Lignocaine HCL 2% was given in all the cases for the desensitization of site of operation. The Clinical parameters were studied before and after 10, 15, 30 and 60 minutes of xylazine sedation. The heart rate was reduced from 67.83 +...

Purpose: Some anesthetic drugs are known to have influence on circulation due hemorheological effects.We aimed investigate the possible effects of ketamin-xylazine anesthesia, which is extensively used inexperimental animal laboratories parameters.Materials and methods: Adult, male Wistar-Albino rats were divided into two as control (pre-anesthesia)and post-anesthesia (n=17). Ketamin-HCl/Xylazi...

BACKGROUND The α2-adrenoceptor agonist xylazine as an anesthetic has been widely used either alone or in combination with other anesthetics, such as ketamine, in veterinary clinic and research. In the last decade xylazine has been used in drug abusers in certain geographic area. This study investigated the effects of xylazine on blood glucose level and insulin secretion in normoglycemic and ins...

Glaucoma is defined as the increase in the intraocular pressure (IOP) causing visual loss due to the circulation deficits of the aqueous humor. The IOP measurement can be obtained without any problem in calm animals. However, some animals do not allow IOP measurement without sedation or anesthesia. The purpose of this study is to determine the effect of xylazine HCl (as a sedative) and ketamine...

Clinical and serum biochemical markers were utilized to assess the clinical efficacy of routinely used preanaesthetics induction agents in rabbits. Eight healthy rabbits (3.0-3.5kg) either sex randomly assigned one two groups: XK (Xylazine-ketamine) or XFK (Xylazine–fentanyl–ketamine). Intramuscular injections xylazine (5 mg/kg), ketamine (35 fentanyl (0.02 mg/kg) given parameters (rectal tempe...

Forty free-ranging elk (Cervus elaphus manitobensis) were captured by net gun in Riding Mountain National Park (Manitoba, Canada) during February 2002 and were administered either saline (control) or xylazine by the intranasal route, to evaluate the efficacy and benefit of intranasal xylazine to reduce stress. Elk that received xylazine had higher relaxation scores than control elk, and the ons...

BACKGROUND/AIM To investigate the influence of thiopental (85 mg/kg, intraperitoneally (ip)), and ketamine+xylazine (ketamine 75 mg/kg and xylazine 8 mg/kg, ip) anesthesia on the incidence and duration of ischemia/reperfusion-induced arrhythmias. MATERIALS AND METHODS Myocardial ischemia was induced by a 6-min ligation of the left anterior descending coronary artery, followed by a 6-min reper...

The effects of premedicating cats with saline, xylazine or medetomidine before anaesthetising them with propofol-sevoflurane were compared. Twenty-four cats were randomly assigned to three groups of eight to receive either 0.25 ml of saline, 0.50 mg/kg of xylazine or 0.02 mg/kg of medetomidine intravenously, and anaesthesia was induced with propofol and maintained with sevoflurane. Medetomidine...