The inhibitory effects of flavonoids on monoamine oxidases (MAOs) have attracted great interest since alterations in monoaminergic transmission are reported to be related to neurodegenerative diseases such as Parkinson's and Alzheimer's diseases and psychiatric disorders such as depression and anxiety, thus MAOs may be considered as targets for the treatment of these multi-factorial diseases. I...

Dracocephalum kotschyi Boiss. has been used as part of an ethnobotanical remedy against many forms of human cancer in Iran. It has been demonstrated that a flavonoid named xanthomicrol from D. kotschyi contributes to its preferential antiproliferative activity against malignant cells. In the present study, the antiproliferative activity of its flavonoid fraction was further characterized. Using...

From an EtOAc extract of Dracocephalum subcapitatum, five flavonoids, calycopterin, xanthomicrol, isokaempferide, luteolin and apigenin, together with five terpenoids, oleanolic acid, ursolic acid, geranial, neral and limonene-10-al, were isolated. Among them, citral and limonene-10-al were the most effective components against epimastigotes of Trypanosoma cruzi, the parasitic agent of Chagas d...

From the overground parts of an endemic Sideritis species, S. stricta, 4 diterpenes, sideridiol (1), isosidol (2), isolinearol (3), and linearol (4); 2 flavonoid glycosides, isoscutellarein 7-O-[6′′′-O-acetyl-β-Dallopyranosyl-(1→2)]-β-D-glucopyranoside (5), and isoscutellarein 7-O-[6′′′-O-acetyl-β-D-allopyranosyl(1→2)]-6′′-O-acetyl-β-D-glucopyranoside (6); a methoxyflavone, xanthomicrol (7); an...

Propolis is a sticky substance made by honeybees from various plant parts that rich in biologically active substances such as flavonoids, phenolic acids, and phenolics has wide range of applications the food, cosmetics, pharmaceutical industries. The current study focused on isolation honeybee propolis samples three different locations Saudi Arabia: Al Hada, Baljurashi, Rawdat Khuraim, evaluati...

An acetone extract obtained from aerial parts of S. stricta Boiss. & Heldr. apud Bentham, its fractions and phenolic compounds were investigated for their in vivo anti-inflammatory and antinociceptive activities. For the anti-inflammatory activity and for the antinociceptive activity assessment, carrageenan-induced hind paw edema and p-benzoquinone-induced abdominal constriction tests were used...