the paper presents the case study of the current formation of a brazilian pit lake from an iron ore mining activity. the water used for the filling of the lake comes from rain, ground water and the complementary pumpage from a close river. at its final stage, which will be reached around year 2018, lake aguas claras will have a surface area of 0.67 km2 and the depth of 234 m, which will make it...

In the eighteenth century, dramatic electrical performances were favourite entertainments for the upper classes, yet the therapeutic uses of electricity also reached the lower strata of society. This change in the social composition of electrical audiences attracted the attention of John Wesley, who became interested in the subject in the late 1740s. The paper analyses Wesley's involvement in t...

There is ample evidence that the use of safety behaviour can interfere with the progress of therapy, particularly if exposure is involved. As a result, it is widely asserted that safety behaviour is anti-therapeutic. However, an unqualified rejection of safety behaviour should be reconsidered because we now have theoretical justification, experimental evidence and clinical observations showing ...

Since the development of monoclonal antibodies twenty-five years ago, researchers and biotech companies have been looking to develop therapeutic uses for them. Michael Gross looks at some of the latest efforts.