conclusions the determination of warfarin dose, based on genotyping, might reduce the time to achieve stable anticoagulation of warfarin dose and length of hospital stay. patients and methods in this prospective cohort study, 200 pediatric patients, who required warfarin therapy after cardiac surgery, were enrolled and divided into two groups. for 50 cases, warfarin was prescribed based on thei...

Warfarin is a vitamin K antagonist that genetic and non-genetic factors affected on its doserequirement in the patients with cardio vascular disease. The aim of this study was whetherthe APOE and VKORC1 polymorphisms influence on warfarin dose requirements in the partof Iranian patients. Blood samples were collected from 86 warfarin-treated patients. Afterextraction of genomic DNA, the VKORC1 (...

atrial fibrillation (af) is associated with inflammatory and hypercoagulability state. previous studies evaluated the safety and efficacy of dabigatran and warfarin in prevention of thrombothic complications. this study was intended to assess the influence of these drugs on hemostatic and inflammatory markers among patient underwent pulmonary vein ablation.   a total of 100 patients with af who...

Background: Many cardiovascular diseases may require lifelong anticoagulation therapy. Warfarin is the most prescribed medication in this regard, however, it has serious side effects. Recently the new issue regarding to warfarin dosing is considered in which some single nucleotide polymorphisms (SNPs) affecting cytochrome P450 system can impact on warfarin metabolism and dosing. Methods: 230 c...

Background: Many cardiovascular diseases may require lifelong anticoagulation therapy. Warfarin is the most prescribed medication in this regard, however, it has serious side effects. Recently the new issue regarding to warfarin dosing is considered in which some single nucleotide polymorphisms (SNPs) affecting cytochrome P450 system can impact on warfarin metabolism and dosing. Methods: 230 c...

Background: Warfarin is a common anticoagulant drug that has a narrow therapeutic index; higher dose causes excessive bleeding and lower dose leads to cerebrovascular clotting and stroke in patients. Genetic factors that have been associated with warfarin response are the genes of cytochrome P450 2C9 (CYP2C9), which metabolize the more active S-enantiomer of warfarin, and vitamin K epoxide redu...

Warfarin is a vitamin K antagonist that genetic and non-genetic factors affected on its doserequirement in the patients with cardio vascular disease. The aim of this study was whetherthe APOE and VKORC1 polymorphisms influence on warfarin dose requirements in the partof Iranian patients. Blood samples were collected from 86 warfarin-treated patients. Afterextraction of genomic DNA, the VKORC1 (...

normal 0 false false false en-us x-none ar-sa microsoftinternetexplorer4 background : many patients using warfarin may be at risk of international normalized ratio fluctuations. this may cause severe massive gastrointestinal or cerebral bleeding. subclinical hypothyroidism in our population is highly prevalent (range from 3.1% to 8.4% for males and females respectively). overt hypothyroidism di...

warfarin induced skin necrosis is a rare complication associated with the use of oral ‎anticoagulants. most patients develop this complication at the initiation of therapy. the complication is ‎usually associated with an underlying thrombophilia. here we describe a case of a 75 year old ‎patient who developed skin necrosis in her both breasts during warfarin treatment for a ‎deep vein thrombosi...