Four polymer-supported benzotriazoles were prepared by linkage of 5-(hydroxymethyl)benzotriazole and benzotrizaole-5-carboxylic acid with Wang resin, Merrifield resin, and (monomethoxy)poly(ethylene glycol). The solid-phase and liquid-phase syntheses of tetrahydroquinolines were achieved by two-pair coupling reactions of aldehydes and aromatic amines using these polymer-supported benzotriazoles...

An efficient three-step solid-phase synthesis of diverse 3,5-disubstituted-2-aminofuranones has been developed. alpha-Hydroxy acids loaded on a nitrophenyl carbonate derivative of Wang resin are used as acylating agents for the C-acylation of active methylene compounds and the resulting intermediates provided, through a cyclative cleavage reaction, the desired product.

A series of substituted diaryltriazoles was prepared by a solid-phase-synthesis protocol using a modified Wang resin. The copper(I)- or ruthenium(II)-catalyzed 1,3-cycloaddition on the polymer bead allowed a rapid synthesis of the target compounds in a parallel fashion with in many cases good to excellent yields. Substituted diaryltriazoles resemble a molecular structure similar to established ...

Cyclic peptides represent a popular class of macrocyclic drug candidates and therefore their solid phase synthesis has attracted much attention. In this contribution we present an efficient method side-chain anchoring for ornithine lysine residues to be used in the standard Fmoc-based cyclic via on-resin cyclization. We demonstrate that side chain protected with N-Boc-group can efficiently conv...

Peptide synthesis: peptides were assembled on an automatic microwave peptide synthesizer, Liberty1 (CEM Corp.), using Fmoc-Gln(Trt)-Wang resin and standard solid phase Fmoc/tBu protocols and HBTU/DIPEA as coupling reagents. Following synthesis completion the peptides were cleaved from the resin by TFA:TIS:H2O – 95:2.5:2.5%. Peptides were purified by semi-preparative RP-HPLC on a JASCO HPLC syst...

A disk Wang-Bézier type generalized Ball curve is a Wang-Bézier type generalized Ball curve whose control points are disks in a plane. It can be viewed as a parametric curve with error tolerances. In this paper, we discuss the problem of degree reduction of disk Wang-Bézier type generalized Ball curve, that is, bounding disk Wang-Bézier type generalized Ball curves with lower degree disk Wa...

Title of dissertation: HIGH ELASTIC MODULUS NANOPOWDER REINFORCED RESIN COMPOSITES FOR DENTAL APPLICATIONS Yijun Wang, Doctor of Philosophy, 2007 Dissertation directed by: Associate Professor Isabel K. Lloyd Department of Material Science and Engineering Dental restorations account for more than $3 billion dollars a year on the market. Among them, all-ceramic dental crowns draw more and more at...