vitamin k is required for the hepatic production of blood coagulation factors ii, vii, ix and x. the term vitamin k refers to a variety of fat-soluble 2-methyl-1, 4-naphthoquinone derivatives. vitamin k1 (phylloquinone) occurs in green plants, while vitamin k2 (menaquinone) is synthesized by microbial in the gut. the recommended dose of vitamin k in neonates is 1 mg intramuscularly. for infants...

Vitamin K is required for the hepatic production of blood coagulation factors II, VII, IX and X. The term vitamin K refers to a variety of fat-soluble 2-methyl-1, 4-naphthoquinone derivatives. Vitamin K1 (phylloquinone) occurs in green plants, while vitamin K2 (menaquinone) is synthesized by microbial in the gut. The recommended dose of vitamin K in neonates is 1 mg intramuscularly. For infants...

The severe adverse reaction to vitamin K1 injection is always remarkable and is thought to result from anaphylaxis. Paradoxically, however, some patients administered vitamin K1 injection for the first time have adverse reactions. Using beagle dogs, the present study tested the hypothesis that the response to vitamin K1 is an anaphylactoid reaction. The results showed that serious anaphylaxis-l...

Background In the past two decades, Vitamin K has been receiving more attention due to its role in bone health and metabolism. The bone mineral density does not remain steady with age, particularly declining after menopause. Objective This study is aimed to investigate the relationship between bone mineral density and serum vitamin K1 levels in post-menopausal women, and to evaluate serum vit...

The purpose of this study was to validate a method for measuring vitamin K isomers in rat tissues by liquid chromatography (LC) with fluorescence detection after simple solvent extraction. This method uses separation on a C30 column, followed by zinc reduction and fluorescence measurement (243 nm, excitation; 430 nm, emission) to detect and quantitate vitamin K isomers. We were able to separate...

This assay for phylloquinone (vitamin K1) in plasma requires a single liquid-chromatographic step. Much smaller volumes of plasma (0.5-1.0 mL) are required than in previous assays. Before liquid chromatography, we purified crude lipid extracts by conventional chromatography on silica, then extracted the lipid fraction by dissolving it in an acidic mixture of hexane/acetonitrile (1/4 by vol) con...

We describe a high-performance liquid chromatographic procedure for the simultaneous measurement of vitamins K1 and E in human serum. Delipidated human serum (free of vitamins K1 and E) was used to make standard solutions of these vitamins, and cetyl naphthoate and alpha-tocopheryl acetate were the internal standards for vitamin K1 and vitamin E, respectively. A simple, novel separation method ...

BACKGROUND Animal studies have shown that vitamin K treatment reduced vascular calcification, but human data are limited. OBJECTIVE We determined the association between vitamin K status and coronary artery calcium (CAC) progression in the Multi-Ethnic Study of Atherosclerosis by using a case-cohort design. DESIGN Serum phylloquinone (vitamin K1) was measured in 296 participants with extrem...

Vitamin K denotes a group of molecules that are needed for the synthesis of certain proteins, mostly required for blood coagulation. Five isoforms of vitamin K exists: vitamin K1, K2, K3, K4, and K5. Vitamin K1 (phytonadione, CAS number 84-800/81818-54-4) has been widely used in cosmetics as it is claimed to reduce the purpura and hyperpigmentation associated with surgical and laser therapies (...

OBJECTIVE The aim of this study was to understand the mechanism of action of vitamin K1 against streptozotocin (STZ)-induced diabetes. METHODS Male Wistar rats were administered 35 mg/kg STZ and after 3 d were treated with vitamin K1 (5 mg/kg, twice a week) for 3 months. Blood glucose was monitored twice a month. At the end of the study, animals were sacrificed and pancreas dissected out and ...