vitamin k is required for the hepatic production of blood coagulation factors ii, vii, ix and x. the term vitamin k refers to a variety of fat-soluble 2-methyl-1, 4-naphthoquinone derivatives. vitamin k1 (phylloquinone) occurs in green plants, while vitamin k2 (menaquinone) is synthesized by microbial in the gut. the recommended dose of vitamin k in neonates is 1 mg intramuscularly. for infants...

Vitamin K is required for the hepatic production of blood coagulation factors II, VII, IX and X. The term vitamin K refers to a variety of fat-soluble 2-methyl-1, 4-naphthoquinone derivatives. Vitamin K1 (phylloquinone) occurs in green plants, while vitamin K2 (menaquinone) is synthesized by microbial in the gut. The recommended dose of vitamin K in neonates is 1 mg intramuscularly. For infants...

The difference between vitamin K metabolism in the liver and that in the bone of vitamin K-deficient rats was examined. After 17 d administration of vitamin K-deficient food, vitamin K in the liver was almost depleted, and prothrombin time (PT) was prolonged. Serum total osteocalcin level was slightly decreased by vitamin K deficiency, whereas serum undercarboxylated osteocalcin level did not c...

The absorption and plasma disappearance of vitamin K were investigated by uniformly labelling phylloquinone in kale with carbon-13, and by feeding the kale to study subjects. Seven healthy volunteers ingested a single 400 g serving of kale with 30 g vegetable oil. The kale provided 156 nmol of phylloquinone. Serial plasma samples were collected and analysed for the appearance of 13C-phylloquino...

A randomised clinical trial was conducted to establish the effects of oral and intramuscular administration of vitamin K at birth on plasma concentrations of vitamin K1, proteins induced by vitamin K absence (PIVKA-II), and clotting factors. Two groups of about 165 healthy breast fed infants who received at random 1 mg vitamin K1 orally or intramuscularly after birth were studied at 2 weeks and...

The prothrombin of the blood is elaborated in the liver. Andrus et al. (1939), and Warren and Rhoads (1939) produced experimental evidence in support, of this hypothesis. By total and partial hepatectomy in animals they produced a profound reduction in plasma prothrombin concentration which was unaffected by treatment with vitamin K and bile salts. It has been found essential to have vitamin K ...

Oral or parenteral administration of vitamin K is the accepted practice for prevention of early vitamin K deficiency bleeding (VKDB) in the newborn. However, vitamin K prophylaxis in the newborn continues to be a worldwide health concern, particularly in breastfed infants. This paper reviews the current status of the use of vitamin K for the prevention of early and late VKDB.