Situs inversus totalis is a rare condition where the visceral organs are organized as a mirror image of default organ position. In this study we picture the co-development between brain and visceral organs in a case of situs inversus totalis from a fetal stage to adolescence and compare our findings to an age-, gender-, and education-matched control with normal position of thoracic and abdomina...

We are studying the development of handedness, in particular the relationships between handed structures with bilateral symmetry, for example the limbs, and those with lateral asymmetry, such as the heart, lungs and gut. Asymmetric (unilateral) developmental limb abnormalities can be induced by chemical treatment of mouse embryos, either in utero by acetazolamide, or in culture by misonidazole....

; Current embryological and anatomical knowledge makes it possible to systematize, classify, and diagnose the malpositions of the heart by following a logical sequence. (i) The visceral situs is easily established by means of data provided by physical, radiological, and electrocardiographic studies. There is a constant relation between the venous atrium, greater lobe of the liver with suprahepa...

Complex congenital heart disease (CHD) is often seen in conjunction with heterotaxy, the randomization of left-right visceral organ situs. However, the link between cardiovascular morphogenesis and left-right patterning is not well understood. To elucidate the role of left-right patterning in cardiovascular development, we examined situs anomalies and CHD in mice with a loss of function allele ...

Situs inversus totalis is a rare congenital anomaly in which position of the heart and all abdominal viscera is reversed. Situs abnormalities usually go unnoticed but may be recognized by radiography or ultrasonography as an incidental finding or during evaluation for congenital heart diseases. We present such an extremely rare and to the best of our knowledge the third reported case of an inju...

Heterotaxy syndrome or situs ambiguous is a rare congenital disease in which the pattern of anatomical organization of the thoraco-abdominal visceral and vascular structures is not arranged in normal position. Patients with heterotaxy syndrome represent a wide range of anatomical variations including thoraco-abdominal structures. Here we report a rare case of asymptomatic heterotaxy syndrome in...

Situs inversus totalis is an uncommon anatomic anomaly that complicates diagnosis and management of acute abdominal pain. Expedient diagnosis of common intraperitoneal disease processes such as biliary colic, acute appendicitis and diverticulitis is often delayed as a result of seemingly incongruous physical findings. We present the case of a young woman with prior emergency room visits for com...

Dextrocardia with situs inversus is a rare congenital abnormality involving a left-handed mal rotation of the visceral organs. The incidence of coronary artery disease is the same as that in the general population. Performing coronary artery bypass surgery on patients with dextrocardia poses a more challenging task. It is recommended that the right internal mammary artery be the first choice of...

Situs inversus, a rare congenital condition, is a complete mirror image of the thoracic and abdominal viscera, in which the positions of major visceral organs are reversed. Here, we report a case of a 6 year old boy who presented with abdominal pain in both the iliac fossae, fever and vomiting. Imaging studies showed situs inversus totalis and a provisional diagnosis of acute appendicitis was m...

KNOWLEDGE of the position of the abdominal organs is important in cardiac diagnosis. Thus a mirror-image dextrocardia is usually observed in a patient with complete situs inversus; this condition more frequently occurs in an otherwise normal individual than in one with a malformed heart. By contrast, when dextrocardia occurs without situs inversus, malformation of the heart is the rule. When th...