following experimental inoculation of 3-week-old turkeys with different titres (106, 104, 103, 102 and 101 egg infectious dose (eid50)) of a/ostrich/italy/984/2000 h7n1 highly pathogenic avian influenza virus (hpaiv), the selected tissues and organs were examined for pathological changes. tissue samples from different organs that obtained from dead and sacrificed birds were fixed in 10% neutral...

BACKGROUND High dose interferon induction treatment of hepatitis C viral infection blocks viral production over 95%. Since dose reduction is often performed due to clinical considerations, the effect of dose reduction on hepatitis C virus kinetics was studied. METHODS A new model that allowed longitudinal changes in the parameters of viral dynamics was used in a group of genotype-1 patients (...

There are many effective chemothereutic agents used in influenza disease which some of them inhibit virus replication by interfering with FluV (influenza virus) viral binding or its penetration into cell membrane. A series of polyoxometalates compounds such as POM-523 and PM-504 have been synthesized and have showed inhibitory effects on viruses. In this study we examined anti influenza activit...

Background and Aims: Despite the screening of blood donors, blood transfusion represents an ideal port of entry for blood-borne infection. Blood-borne pathogen transmission has been a concern since the earliest days of transfusion. The blood product of platelet (PLT) concentrates is still faced with the risk of bacterial and viral contaminations. Pathogen inactivation technologies offer a proac...

Background and Aims: Despite the screening of blood donors, blood transfusion represents an ideal port of entry for blood-borne infection. Blood-borne pathogen transmission has been a concern since the earliest days of transfusion. The blood product of platelet (PLT) concentrates is still faced with the risk of bacterial and viral contaminations. Pathogen inactivation technologies offer a proac...

BACKGROUND The aim of the study was to analyze the different impact of standard and low-dose Peg-IFN-α2a/RBV therapies on HCV viral decline in HIV/HCV genotype 3 co-infected patients during the first weeks of treatment. METHODS Plasma HCV viral decline was analyzed between baseline and weeks 1, 2 and 4 in two groups of treatment-naïve HCV genotype 3 patients with HIV co-infection. The Standar...

there are many effective chemothereutic agents used in influenza disease which some of them inhibit virus replication by interfering with fluv (influenza virus) viral binding or its penetration into cell membrane. a series of polyoxometalates compounds such as pom-523 and pm-504 have been synthesized and have showed inhibitory effects on viruses. in this study we examined anti influenza activit...

Introduction: Nitazoxanide is an oral anti-parasitic agent that has been found to have broad antiviral activity. Its role in the treatment of viral gastroenteritis is not well-studied. Given the worldwide prevalence of viral gastroenteritis, particularly in developing nations, a systematic review of this topic would be valuable. Methods: A formal literatu...