In present study, a mathematical model of the vehicle–floating slab track (FST) interaction is established to investigate the coupled behaviour of vehicle–track system. The FST is modelled as the double Euler -Bernoulli beam including the rail and slab. The railway vehicle is simplified as a multi-rigid-body model. The wheel–rail interface is treated using a nonlinear Hertzian contact model, co...

Background and objectives: Considering the increasing prevalence of depression, many studies are launched to investigate new antidepressant treatments. The present research has shown how psilocybin as an active compound of Psilocybe cubensis (Earle) Singer extract (PCE) can change the parameters related to depression and anxiety in animal models. Both ...

The mortality of individuals suffering from depression has been increasing, especially post-menopausal women; therefore, their care and treatment are important to maintain a high quality of life. In the present study, we evaluated the antidepressant-like effects of a major isoflavonoid, genistein (4',5,7-trihydroxyisoflavone), using a behavioral model of depression, the forced swimming test (FS...

Environmental factors play a key role in the etiology of depression. The rodent forced swim test (FST) is commonly used as a preclinical model of depression, with increases in escape-directed behavior reflecting antidepressant effects, and increases in immobility reflecting behavioral despair. Environmental enrichment leads to serotonergic alterations in rats, but it is unknown whether these al...

Antagonism of the kappa opioid receptor (KOR) has been reported to have anti-depressant-like properties. The dynorphin/KOR system is a crucial neurochemical substrate underlying the pathologies of addictive diseases, affective disorders and other disease states. However, the molecular underpinnings and neuroanatomical localization of the dysregulation of this system have not yet been fully eluc...

Curcumin is the active ingredient of commonly used spice Curuma longa Linn. In the present study, the antidepressant like activity of curcumin and its combination with fluoxetine and imipramine was studied in acute model (three doses 24, 5 and 1 h before test) of forced swimming test (FST) in glass jar and tail suspension test (TST) in mice and in chronic model (14 day study) of FST with water ...

BACKGROUND The forward surgical team (FST) is the US Army's smallest surgical element. These teams have supported current conflicts since 2001. The purpose of this study was to determine if surgeon utilization varied at two different FSTs and to determine factors that may predict the need for a surgeon. METHOD Data from two FSTs were reviewed. A t-test was used to compare the military injury ...

The present study was undertaken to evaluate the anti-depressive activity of a polyherbal formulation (PF) after 28 days administration by using a rat forced swimming test (FST) and tail suspension test (TST). Animals were divided into six groups (n=6/group): group-1: The control rats received injections of 0.5% CMC solution only; group 2: FST+vehicle, groups 3: FST+SER (10 mg/kg, i.p.); group ...

Laminar-to-turbulent transition in a swept flat-plate boundary layer is caused by the breakdown of crossflow vortex via high-frequency secondary instability and promoted wall-surface roughness freestream turbulence (FST). Although FST characterized its intensity wavelength, it not clear how wavelength affects turbulent transitions interacts with roughness-induced transition. The depends on wind...

Estrogen administration elicits anxiolytic and antidepressant-like effects in female rats; however, the mechanism of this effect is unknown. Fatty acid amide hydrolase (FAAH), the enzyme which degrades the endocannabinoid anandamide, has been shown to be regulated by estrogen. Thus, we examined if the anxiolytic and antidepressant effects of estrogen implicated the endocannabinoid system. In th...