PURPOSE The aims of this study were to determine the prevalence of vitreomacular adhesion (VMA) in a random sample of clinical patients at three US retina clinics and to assess comorbid retinal conditions, ocular diseases, prior treatment history, and other medical histories. PATIENTS AND METHODS This observational, retrospective cohort study was based on patients from the Doheny Eye Centers,...

Herein, we review the association between vitreomacular adhesion (VMA) and neovascular age-related macular degeneration (AMD). Meta-analyses have shown that eyes with neovascular AMD are twice as likely to have VMA as normal eyes. VMA in neovascular AMD may induce inflammation, macular traction, decrease in oxygenation, sequestering of vascular endothelial growth factor (VEGF), and other cytoki...

Vaccinium myrtillus L. anthocyanoside (VMA) is used as a folk medicine to treat diseases related to gastric ulcers in northern Europe. However, the effects of VMA and its detailed mechanism on gastric ulcer have not been investigated sufficiently. Therefore, the aim of the present study was to investigate the protective effects of VMA on gastric mucosal damage in a murine gastric ulcer model. F...

PURPOSE To investigate the effect of vitreomacular adhesion (VMA) on the outcome of antiangiogenic treatment for neovascular age-related macular degeneration (AMD). METHODS Ninety-nine eyes of 83 patients were used in our cohort study. We prospectively evaluated best corrected visual acuity (BCVA) and central retinal thickness (CRT) in patients with neovascular AMD at baseline and 1, 2, 3, 6,...

PURPOSE To investigate whether vitreomacular adhesion (VMA) affects the outcome of anti-vascular endothelial growth factor (VEGF) therapy for the treatment of exudative age-related macular degeneration (AMD) in Japanese patients. SUBJECTS AND METHODS Of 88 Japanese AMD patients (28 men and 60 women, mean age: 72.7±7.5 years) who underwent intravitreal injection of ranibizumab for 3 years from...

To analyze the phenotype of cells lacking the vacuolar ATPase, we inactivated the vma-1 gene, which encodes the catalytic subunit of the enzyme. Because preliminary experiments suggested the vma-1 gene was essential, we developed a method of simultaneously inactivating the gene and complementing it with a functional copy. We call this method repeat-induced point mutation (RIP) & Rescue. Two str...

In eighteen normal healthy volunteers, the effect of cigarette smoking, coffee drinking and alcohol consumption on adrenomedullary sympathetic function was assessed in terms of urinary VMA levels. Following the indulgence in all these social habits, urinary VMA levels are significantly increased. The maximum and minimum increase in VMA levels were recorded following coffee drinking and alcohol ...

A simple and accurate method for the determination of urinary 3-methoxy-4-hydroxy-mandelic acid, vanillyl-mandelic acid (VMA), is described. The separation of VMA from all other phenolic acids in approximately 0.05 ml. untreated urine is achieved by using low-voltage paper electrophoresis with different buffer concentrations for the cathode and the anode. The concentration of the electrophoreti...

Epidemiologic and clinical studies have related acute and, less frequently, chronic life stress to cardiovascular diseases. In addition, animal models suggest that chronic psychological stress could cause atherosclerosis, probably by increasing sympathetic activation. In this cross-sectional study we evaluated the association between job strain, as one of the markers of workplace stress, and th...

The relationship between homovanillic acid (HVA), vanillylmandelic acid (VMA), and creatinine in the urine of 6 month old babies has been studied and reference ranges in the form of centiles constructed for HVA and VMA against creatinine. Over 10,000 urine samples were collected from babies in four health districts in the north of England. HVA and VMA concentration, either independently or when...