objective: unexplained recurrent spontaneous abortion (ursa) is one of the main complications of pregnancy which is usually defined as three or more consecutive pregnancy losses before the 20th week of gestation without a known cause. vascular endothelial growth factor (vegf) is a potent angiogenic factor and shown, along with its receptors (vegfr1, 2), to play important roles in several physio...

background: establishment of viable pregnancy requires embryo implantation and placentation. ectopic pregnancy (ep) is a pregnancy complication which occurs when an embryo implants outside of the uterine cavity, most often in a fallopian tube. on the other hand, an important aspect of successful implantation is angiogenesis. vascular endothelial growth factor (vegf) is a potent angiogenic facto...

Background Establishment of viable pregnancy requires embryo implantation and placentation. Ectopic pregnancy (EP) is a pregnancy complication which occurs when an embryo implants outside of the uterine cavity, most often in a fallopian tube. On the other hand, an important aspect of successful implantation is angiogenesis. Vascular endothelial growth factor (VEGF) is a potent angiogenic factor...

Background: Endometriosis is a disease which is defined by the growth of endometrium-like tissue outside of the uterine cavity. Literatures show that VEGF by interaction with their receptors, Flt-1 (Fms-like tyrosine kinase-1 or VEGFR-1) and Flk-1/KDR (fetal liver kinase/ kinase-insert domain receptor or VEGFR-2) is related to pathogenesis of endometriosis. The purpose of this study was to eval...

Background: Mesenchymal stem cells (MSCs) are multipotent that can differentiate into several cell types including chondrocytes and osteocytes. The process of differentiation such tissues is aided by transcription factors collagen gene markers. Collagen biosynthesis influenced the presence vascular endothelial growth factor (VEGF) ascorbic acid cofactors prolyl hydroxylase 2 (PHD2) enzyme found...

Background: Ectopic pregnancy (EP) is a complication of conception in which the embryo implants outside of uterine cavity. The increasing incidence of serious maternal morbidity resulting from EP has prompted the search for biomarkers to aid in early diagnosis and take advantage of conservative treatments. One of the effective biomarkers in EP is vascular endothelial growth factor (VEGF). VEGF ...

Recent research has shown that VEGF may influence the condition and survival of patients with chronic kidney disease (CKD), including those treated dialysis procedures. Identifying value this factor is important to uncover mechanisms CKD progression improve treatment strategies.
 The present study aimed determine mean serum levels vascular endothelial growth (VEGF) its receptor (VEGF-R) th...

Specific proteolytic cleavages turn on, modify, or off the activity of vascular endothelial growth factors (VEGFs). Proteolysis is most prominent among lymph­angiogenic VEGF-C and VEGF-D, which are synthesized as precursors that need to undergo enzymatic removal their C- N-terminal propeptides before they can activate receptors. At least five different proteases mediate activating cleavage VEGF...

objective: vascular endothelial growth factor (vegf) and vegf receptors (vegfrs) play important roles in angiogenesis of different developmental mechanisms such as wound healing, embryogenesis and diseases, including different types of cancer. vegfr2 is associated with cell proliferation, migration, and vascular permeability of endothelial cells. blocking vegf and its receptors is suggested as ...

Background: Endometriosis is the presence of endometrium- like tissue in sites outside the uterine cavity, primarily on the pelvic peritoneum and ovaries. Ectopic endometrium for replacement and growth require to blood supply. Vascular endothelial growth factor (VEGF) is one of the most important intermediate of locality angiogenesis that product by monocytes and macrophages. This study evaluat...