نتایج جستجو برای: VCM

تعداد نتایج: 403  

Journal: :Antimicrobial agents and chemotherapy 1996
K Nishihara T Shimizu H Kotaki Y Sawada T Okuno K Kaga T Murofushi T Iga

The dispositions of vancomycin (VCM) and gentamicin (GM) in plasma and perilymph after single and multiple administrations and the effects of multiple administrations of VCM or GM alone and the combination of both drugs on auditory function were studied in male guinea pigs. The pharmacokinetic parameters of VCM and GM obtained from plasma drug concentration-time data after single and multiple (...

2014
Nicolas Griffon Gaétan Kerdelhué Lina Fatima Soualmia Tayeb Merabti Julien Grosjean Jean-Baptiste Lamy Alain Venot Catherine Duclos Stéfan Jacques Darmoni

BACKGROUND Visualization of Concepts in Medicine (VCM) is a compositional iconic language that aims to ease information retrieval in Electronic Health Records (EHR), clinical guidelines or other medical documents. Using VCM language in medical applications requires alignment with medical reference terminologies. Alignment from Medical Subject Headings (MeSH) thesaurus and International Classifi...

Journal: :Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 2010
Shinichi Sadoh Yasuhiro Tsuji Kazuhiro Tsukamoto

Vancomycin (VCM) is a glycopeptide antibiotic that is generally used to treat methicillin-resistant Staphylococcus aureus (MRSA). Recently, it has been reported that VCM clearance (CL) is significantly higher in elderly patients and infants and children with malignancies, compared with those without malignancies. We have treated many patients with a variety of malignant tumors in whom serum VCM...

Journal: :Biological & pharmaceutical bulletin 2002
Hitomi Teramachi Hiromi Hatakeyama Ryo Matsushita Yukio Imai Ken'ichi Miyamoto Akira Tsuji

The predictability of serum vancomycin (VCM) concentrations by means of the Bayesian method was evaluated to establish whether the method can be used to select safe and effective VCM treatment regimens for individual patients. Serum VCM concentrations at the trough and 2 h after the end of infusion (peak) were measured. Pharmacokinetic parameters were calculated for VCM dosage regimens based on...

2017
Tetsuro Hida Kei Ando Kazuyoshi Kobayashi Kenyu Ito Mikito Tsushima Akiyuki Matsumoto Masayoshi Morozumi Satoshi Tanaka Masaaki Machino Kyotaro Ota Shunsuke Kanbara Sadayuki Ito Yoshihiro Nishida Naoki Ishiguro Shiro Imagama

Surgical site infections (SSIs) are one of the most serious complications in spine surgery. We investigated the efficacy of locally administered vancomycin (VCM) powder for prophylaxis on SSI after invasive spine surgery. We retrospectively studied 174 consecutive patients who underwent spine surgery. In patients of the VCM group (n = 81), VCM powder was administered in the wound before closing...

Journal: :Food and cosmetics toxicology 1981
V J Feron C F Hendriksen A J Speek H P Til B J Spit

A lifespan oral toxicity study of vinyl chloride monomer (VCM) was carried our in Wistar rats, using five groups each of 60-80 males and 60-80 females. VCM was administered by incorporating polyvinyl chloride (PVC) powder with a high VCM content into the diet or by gastric intubation of a 10"/o VCM solution in soya-bean oil. The VCM doses (actual exposures) were 0 (control~ 1·7. 5·0 and 14·1 mg...

2015
Kenichi Ishii Fumiaki Tabuchi Miki Matsuo Keita Tatsuno Tomoaki Sato Mitsuhiro Okazaki Hiroshi Hamamoto Yasuhiko Matsumoto Chikara Kaito Tetsuji Aoyagi Keiichi Hiramatsu Mitsuo Kaku Kyoji Moriya Kazuhisa Sekimizu

The development of vancomycin (VCM) resistance in Staphylococcus aureus threatens global health. Studies of the VCM-resistance mechanism and alternative therapeutic strategies are urgently needed. We mutagenized S. aureus laboratory strains and methicillin-resistant S. aureus (MRSA) with ethyl methanesulfonate, and isolated mutants that exhibited high resistance to VCM (minimum inhibitory conce...

2015
Keizo Fukushima Akira Okada Yoriko Hayashi Hideki Ichikawa Asako Nishimura Nobuhito Shibata Nobuyuki Sugioka

Long-term parenteral nutrition (PN) can induce intestinal atrophy, leading to a loss of epithelial integrity in the small intestines. This change may alter the intestinal permeability of vancomycin (VCM), a non-absorbable antibiotic. The aim of the present study was to investigate the effect of PN on the pharmacokinetics of VCM in rats. VCM was intravenously (5 mg/kg) or intraduodenally (20 mg/...

2015
Toshiyuki Sakimura Shiro Kajiyama Shinji Adachi Ko Chiba Akihiko Yonekura Masato Tomita Hironobu Koseki Takashi Miyamoto Toshiyuki Tsurumoto Makoto Osaki

We investigated biofilm formation and time of vancomycin (VCM) resistance expression after adhesion to a metal surface in Staphylococcus epidermidis. Biofilm-forming Staphylococcus epidermidis with a VCM MIC of 1 μg/mL was used. The bacteria were made to adhere to a stainless steel washer and treated with VCM at different times and concentrations. VCM was administered 0, 2, 4, and 8 hours after...

Journal: :Journal of occupational and environmental medicine 2001
T J Cheng Y F Huang Y C Ma

Thiodiglycolic acid (TdGA) is the major metabolite of vinyl chloride monomer (VCM) detected in human urine. Although urinary TdGA has been reported to be associated with ambient VCM exposure, the relationship between urinary TdGA and a low level of air VCM is not clear. Questionnaires were administered to 16 polyvinyl chloride manufacturing workers to obtain a detailed history of occupation and...

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