Fracture assessment of U- and V-notches is important in mechanical engineering. One can use the J-integral as fracture parameter in order to predict the critical fracture load in notches. The critical value of the J-integral in cracks is a function of the material properties. In notches, however, the material properties as well as the notch dimensions affect this critical value (named fracture ...

sudden fracture is one of the major failure modes in brittle materials. plexiglass (polymethyl methacrylate) is a well known brittle polymer, widely used in various industries. many types of notches, particularly v-shaped notches, are sometimes used in the components made of plexiglass. these notches can dramatically decrease the load bearing capacity of components due to the concentration of s...

Notch signaling in prominently involved in growth regulation in metazoan tissues. Because of this, Notch is often upregulated in cancer and current efforts point to developing drugs that block its activation. Notch receptor endocytosis towards acidic compartments is a recently appreciated determinant of signaling activation. Vacuolar H(+) ATPase (V-ATPase) is responsible for acidification of en...

Evidence indicates that endosomal entry promotes signaling by the Notch receptor, but the mechanisms involved are not clear. In a search for factors that regulate Notch activation in endosomes, we isolated mutants in Drosophila genes that encode subunits of the vacuolar ATPase (V-ATPase) proton pump. Cells lacking V-ATPase function display impaired acidification of the endosomal compartment and...

A three-dimensional failure initiation criterion in brittle materials containing a sharp V-notch is presented and validated by experiments. It is based on simultaneous fulfilment of the stress requirement and a finite fracture mechanics energy release rate (ERR) requirement. Since the ERR cannot determine failure initiation direction for dominant mode III loading, the failure initiation orienta...

Suprascapular notch is characterized by variable morphology. However, its development is not well studied. We hypothesize that it proceeds postnatally. Thus, the aim of this research was to characterize the morphology of the suprascapular notch in a pediatric population based on computed tomography. A retrospective analysis was performed of 291 chest computed tomography examinations of patients...

Kaposi's sarcoma herpesvirus (KSHV)-encoded v-cyclin, a homolog of cellular cyclin D2, activates cellular CDK6, promotes G1-S transition of the cell cycle, induces DNA damage, apoptosis, autophagy and is reported to have oncogenic potential. Here we show that in vivo expression of v-cyclin in the B- and T-cell lymphocyte compartments results in a markedly low survival due to high penetrance of ...

In regards to the problem of tubing precision separation, high-efficiency separation method for under eccentric wheel high-speed rotational bending fatigue loading is proposed, which aims promote initiation cracks at root annular V-notch on surface. Research stress concentration effect notch surface carried out. The design takes into account characteristics separation. numerical simulation calc...