نتایج جستجو برای: Uterine NK cell

تعداد نتایج: 1723402  

Journal: :iranian journal of immunology 0
abdolkarim sheikhi departments of immunology hossein b. ganji and anatomy, school of medicine, zanjan university of medical sciences, zanjan, iran razieh sheikhi department of environmental health, faculty of health sciences, tehran university of medical sciences, tehran, iran

background: uterine natural killer (unk) cells are the most abundant leukocytes in pre-implantation endometrium and early pregnancy deciduas in humans and rodents. they are associated with structural changes in maternal spiral arteries but regulation of their re-cruitment and activation is incompletely understood. the major subpopulation of unk cells in humans expresses cd56, the neural cell ad...

2014
Jens Kieckbusch Louise M. Gaynor Ashley Moffett Francesco Colucci

NK cells express variable receptors that engage polymorphic MHC class I molecules and regulate their function. Maternal NK cells accumulate at the maternal-fetal interface and can interact with MHC class I molecules from both parents. The relative contribution of the two sets of parental MHC molecules to uterine NK cell function is unknown. Here we show that, in mice, maternal and not paternal ...

آذرفام, پروین, تقی زاده, صغری, حسین پور فیضی, محمد علی, منتظری, وحید, پولادی, ناصر,

Introduction: Immunological processes play an important role in recurrent spontaneous abortion(RSA). According to studies, T lymphocytes and natural killer cells(NK cells) are two effective cell groups in RSA. The aim of this study was to study the percentage and absolute number of natural killer(NK) cells in women with RSA of unknown etiology. Methods: A total of 24 women with history of recu...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2011
Damayanti Chakraborty M A Karim Rumi Toshihiro Konno Michael J Soares

Natural killer (NK) cells are recruited into the uterine stroma during establishment of the hemochorial placenta and are proposed regulators of uterine spiral artery remodeling. Failures in uterine spiral artery remodeling are linked to diseases of pregnancy. This prompted an investigation of the involvement of NK cells in placentation. NK cell depletion decreased the delivery of proangiogenic ...

2015
Roberta Rizzo Giuseppe Lo Monte Daria Bortolotti Angela Graziano Valentina Gentili Dario Di Luca Roberto Marci

The aim of this research was to determine the levels of human leukocyte antigen G (HLA-G) and endometrial Natural Killer ((e)NK) cell percentages in uterine flushing samples from primary and secondary infertile women. sHLA-G levels were lower in the uterine flushing samples from primary infertile women in comparison with women with secondary infertility. Lower CD56+KIR2DL4+ (e)NK cell percentag...

2016
Ricardo C Cavalli Ana Sofia Cerdeira Elizabeth Pernicone Henri A Korkes Suzanne D Burke Augustine Rajakumar Ravi I Thadhani Drucilla J Roberts Manoj Bhasin S Ananth Karumanchi Hernan D Kopcow

Decidual NK (dNK) cells, a distinct type of NK cell, are thought to regulate uterine spiral artery remodeling, a process that allows for increased blood delivery to the fetal-placental unit. Impairment of uterine spiral artery remodeling is associated with decreased placental perfusion, increased uterine artery resistance, and obstetric complications such as preeclampsia and intrauterine growth...

Journal: :Reproductive BioMedicine Online 2008

Journal: :Journal of immunology 2010
Victoria Male Tiffany Hughes Susan McClory Francesco Colucci Michael A Caligiuri Ashley Moffett

NK cells are the dominant population of immune cells in the endometrium in the secretory phase of the menstrual cycle and in the decidua in early pregnancy. The possibility that this is a site of NK cell development is of particular interest because of the cyclical death and regeneration of the NK population during the menstrual cycle. To investigate this, we searched for NK developmental stage...

2017
Locke D. Uppendahl Carly M. Dahl Jeffrey S. Miller Martin Felices Melissa A. Geller

Harnessing the immune system has proven an effective therapy in treating malignancies. Since the discovery of natural killer (NK) cells, strategies aimed to manipulate and augment their effector function against cancer have been the subject of intense research. Recent progress in the immunobiology of NK cells has led to the development of promising therapeutic approaches. In this review, we wil...

2011
Victoria Male Andrew Sharkey Leanne Masters Philippa R Kennedy Lydia E Farrell Ashley Moffett

The major leukocyte population in the decidua during the first trimester of pregnancy consists of NK cells that express receptors capable of recognizing MHC class I molecules expressed by placental trophoblast. These include members of the killer immunoglobulin-like receptor (KIR) family, the two-domain KIR (KIR2D), which recognize HLA-C. Interactions between decidual NK (dNK) cell KIR2D and pl...

نمودار تعداد نتایج جستجو در هر سال

با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید