mediator complex subunit 12 (med12) is a part of the mediator complex, which is believed to regulate transcription. med12 is mutated at high frequency and with different mutation frequencies in uterine fibroids and breast fibroadenomas of different populations. this study aimed to analyze med12 mutations in senegalese population. med12 was sequenced in the tumoral tissues and blood samples of s...

background:   uterine myomas are common pelvic masses during pregnancy. the pain and rapid growth of myomas are among the most common complications during pregnancy. we evaluate management of painful cystic degeneration of myomas during pregnancy case: a 27-year-old primigravida had a pelvic mass. we have managed a case in which the diagnosis of cystic degeneration of uterine myomas could not b...

Certain dietary components which could affect oestrogen may have implications in the aetiology of uterine fibroids. We previously found that soya intake was inversely associated with a subsequent risk of hysterectomy, suggesting a potentially protective effect of soya against uterine fibroids, the major clinical indication for hysterectomy. We cross-sectionally assessed the associations of inta...

Mediator complex subunit 12 (MED12) is a part of the mediator complex, which is believed to regulate transcription. MED12 is mutated at high frequency and with different mutation frequencies in uterine fibroids and breast fibroadenomas of different populations. This study aimed to analyze MED12 mutations in Senegalese population. MED12 was sequenced in the tumoral tissues and blood samples of S...

The aim of this article is to analyze factors affecting sonication dose and build a dosimetry model of high-intensity focused ultrasound (HIFU) ablation for uterine fibroids. Four hundred and three patients with symptomatic uterine fibroids who underwent HIFU were retrospectively analyzed. The energy efficiency factor (EEF) was set as dependent variable, and the factors possibly affecting sonic...

Uterine fibroids are benign monoclonal neoplasms of the myometrium, representing most common tumors in women worldwide. To date, no long-term or noninvasive treatment option exists for hormone-dependent uterine fibroids, due to limited knowledge about molecular mechanisms underlying initiation and development fibroids.

OBJECTIVE To investigate the impact of fibroids on the blood flow of the uterine and subendometrial arteries and in vitro fertilization (IVF) outcomes. METHODS In this study, we analyzed 86 IVF/intracytoplasmic sperm injection (ICSI) cycles in which a gonadotropin-releasing hormone antagonist protocol was used for controlled ovarian stimulation between January 2008 and March 2009. The subject...

Background: Uterine leiomyomas (fibroids) are now known to be highly variable in their clinical behavior and biologic basis. However, the approach to leiomyomas and their effect on fertility, miscarriage and pregnancy complications has been based on location alone. Materials and Methods: This talk with bring together published information on the effect of leiomyomas on reproductive performance ...

Overview: Uterine leiomyomas (fibroids or myomas) are benign tumors. Since histologic confirmation of the clinical diagnosis is not necessary in most cases, and there is both growth and regression of fibroids, asymptomatic uterine leiomyomas can usually be followed without intervention. Research supports not treating asymptomatic fibroids. Treatments for symptomatic fibroids include medical man...

T he uterus is the most common site to develop smooth muscle tumors. Uterine fibroids (leiomyomas) contain benign smooth muscle and fibrous tissues. Twenty percent to 40% of reproductive age women develop uterine fibroids, with a higher incidence in African Americans. Although the decline in hormonal stimulation causes most fibroids to regress at menopause, 20% become symptomatic before then. U...