objective(s): we aimed to study the effect of trimetazidine (tmz) on urethral wound repair. materials and methods: a total of 52 male rats were used; 8 groups were formed: 1-week and 3-week control (c1,c3), sham (s1, s3), oral (ot1, ot3), and intraurethral tmz (iut1, iut3) groups. serum and urine total antioxidant capacity (tac), total oxidant capacity (toc), and 8-hydroxy-deoxy-guanosine (8-oh...

a seven-year-old stallion with diversion of urinary pass to the thigh due to a urethral fistula caused by gunshot perineal injury was presented to the urmia university, veterinary teaching hospital. no signs of urinary obstruction or renal failure were observed. because of inaccessible location of the injured urethra, through a perineal urethrotomy incision, a urinary catheter was effectively a...

A seven-year-old stallion with diversion of urinary pass to the thigh due to a urethral fistula caused by gunshot perineal injury was presented to the Urmia University, Veterinary Teaching Hospital. No signs of urinary obstruction or renal failure were observed. Because of inaccessible location of the injured urethra, through a perineal urethrotomy incision, a urinary catheter was effectively a...

Urethral healing is plagued by strictures, impacting quality of life and medical costs. Various growth factors (GFs) have shown promise as therapeutic approaches to improve healing, but there no protocol for in vitro comparison between GFs. This study focuses the development a biomimetic urothelial assay designed mimic early vivo followed an evaluation cell response Methods: Wound-healing assay...

Objective(s): We aimed to study the effect of trimetazidine (TMZ) on urethral wound repair. Materials and Methods: A total of 52 male rats were used; 8 groups were formed: 1-week and 3-week control (C1,C3), sham (S1, S3), oral (OT1, OT3), and intraurethral TMZ (IUT1, IUT3) groups. Serum and urine total antioxidant capacity (TAC), total oxidant capacity (TOC), and 8-hydroxy-deoxy-guanosine (8-O...

The use of bovine pericardium as a urethral patch to substitute a ventral segment of canine urethras was studied. Healing, epithelial growth, urethral permeability, fistulas, and calcification were analyzed. Thirty male mongrel dogs of medium and large size underwent resection of a ventral segment of the medial urethra measuring 2.0 x 0.5 cm, which was replaced with a bovine pericardium graft, ...

PURPOSE Buccal mucosa is a widely accepted tissue for urethroplasty. The exact healing and tissue integration process, mainly the histological characteristics of dorsal buccal mucosa graft urethroplasty when used dorsally to reconstruct the urethral plate has not previously been assessed, and thus we developed an experimental model to address this question. MATERIALS AND METHODS In 12 New Zea...

OBJECTIVES Tensile distracting forces caused by elements such as a muscle pull can cause widening of scars in the tissue during the wound healing process. The aim of the present study was to investigate whether induced immobilization of the urethral muscle using botulinum toxin-A (BTX-A) enhances wound healing and also reduces the amount of scar formation in an experimentally induced urethral i...

background: the treatment of urethral stricture in female patients is through dilatation of the urethra by tubes of increasing diameter. there are two main methods: intermittent dilatation and on demand dilatation. objectives: the main aim of this study was to compare the results of these two methods, and to determine the best one. patients and methods: in this clinical trial study, we reviewed...

A 63-year old man was referred to us after three rapid recurrences of low-grade urethral papillary transitional cell carcinoma of the bulbar urethra, after repeated primary excision. Cystoscopy confirmed 3-4 low-grade urethral transitional cell carcinomas, which were subsequently fulgurated. After urethral healing, a solution of Mitomycin C (40 mg/80 cc) was instilled into the urethra for fifte...