Soft tissue sarcomas are a heterogeneous group of tumors with many different subtypes. In 2014 an estimated 12,020 newly diagnosed cases and 4,740 soft tissue sarcoma related deaths can be expected in the United States. Many soft tissue sarcomas are associated with poor prognosis and therapeutic options are often limited. The evolution of precision medicine has not yet fully reached the clinica...

Primary cardiac tumors are very rare. Cardiac sarcomas can be detected at any age, regardless of gender. At diagnosis, these mostly symptomatic and one-third metastatic. Undifferentiated pleomorphic account for 1.7% all tumors, typically localized in the left atrium, involve mitral valve. Here we present a case atrial undifferentiated sarcoma with myogenic differentiation that clinically radiol...

Undifferentiated sarcomas, more correctly known as undifferentiated pleomorphic sarcomas (UPS), are a form of soft tissue sarcoma. They appear to be uncommonly diagnosed in veterinary species but represent the second most common sarcoma human adults. There is an evolving nomenclature around these tumours, with older reports referring ‘malignant fibrous histiocytoma’, have been reclassified into...

Intraluminal formations of the heart are a heterogeneous group: from blood clots to malignant neoplasms. The nosology these can only be determined by morphological research. Myxofibrosarcoma is rare tumor. According modern concepts, myxofibrosarcoma belongs group intimal sarcomas, subgroup undifferentiated pleomorphic sarcomas. We describe two cases heart: in one subject against background infl...

Introduction: Sarcomas account for 1% of all tumors originated in the head and neck regions in adults. They constitute a heterogeneous group of tumors of mesenchymal origin with multiple histological variants. The undifferentiated pleomorphic sarcoma (UPS) subtype is the most frequent variant with an incidence range of 2.7-38%.   Materials and Methods: This retrospective...

Objective: Various genetic alterations including inactivation of tumor suppressor genes and activation of oncogenes, are described in different types of neoplasms as well as soft-tissue tumors. The purpose of the present study is to evaluate the expressions of mdm2 and p53, and Ki-67 proliferative activity and to investigate their interrelations with the clinicopathologic parameters in fibrohis...

Renal cell cancers are the most prevalent type of malign renal masses. Sarcomas are one of the rarest subtypes. Primary renal sarcomas make up 1e3% of all renal malign masses. Previously known as malign fibrosis histiocytoma (MFH), pleomorphic undifferentiated sarcoma (PUS) is the most prevalent soft tissue tumor in adults, with a 20% occurrence rate. PUS has a histologically wide range, the mo...

Dear Editor, By definition, sarcomas are malignant tumors of tissues, derived from mesoderm and involve the oncogenic transformation of mesenchymal stem cells. The two main types of sarcoma are bone and soft tissue sarcomas. Soft tissue sarcomas generally manifest as deep lesions, but they may affect the skin and subcutaneous tissue.1 They are grouped according to similarities in their clinical...

INTRODUCTION Rarely, the dermatologistmay encounter a primary cutaneous pleomorphic sarcoma (also known as a malignant fibrous histiocytoma), an undifferentiated neoplasm thought to be of mesenchymal origin. These uncommon skin tumors typically manifest as tender subcutaneous nodules. In contrast to primary cutaneous sarcomas, we present a case of a soft tissue pleomorphic sarcomawithmultiple m...