One hundred methanol plant extracts were screened for antibiotic activity against Mycobacterium tuberculosis and Mycobacterium avium. Nineteen extracts exhibited some activity against M. tuberculosis and 16 extracts showed some activity against M. avium. Thirteen of these 19 active extracts were traditionally used by First Nations peoples to treat tuberculosis. Extracts made from Heracleum maxi...

Furanocoumarins in grapefruit are known to show inhibitory effects against P-glycoprotein and/or CYP3A4 in intestinal epithelial cells; however, furanocoumarin derivatives are widely contained in the plants of rutaceae and umbelliferae families, which are used as components of Kampo extract medicines. In this study, we investigated the inhibitory effects of 12 furanocoumarins extracted from pla...

Furanocoumarins in grapefruit are known to show inhibitory effects against P-glycoprotein (P-gp) and CYP3A4 in intestinal epithelial cells; however, furanocoumarin derivatives are widely contained in the plants of Rutaceae and Umbelliferae families, which are used as components of Kampo extract medicines. In this study, we investigated the inhibitory effects of 12 furanocoumarins extracted from...

The Umbelliferae is a large and taxonomically complex family of flowering plants whose phylogenetic relationships, particularly at low taxonomic levels, are generally obscure based on current and widely used molecular markers. Thus, information on the phylogenetic utility of additional molecular markers at these levels is highly favorable. We investigate the utility of nuclear ribosomal DNA (nr...

The plant family Umbelliferae (Apiaceae) consists of almost 3000 species worldwide (112). Members of the family occupy a wide variety of habitats, including deserts, basaltic bluffs, salt and freshwater marshes, chaparral, forests, waste places, and subalpine tundra. Despite the ecological diversity, however, family members display remarkable morphological conservatism. The integrity of the fam...