نتایج جستجو برای: UBE2B ژن

تعداد نتایج: 15794  

2016
Cécile Polge Roza Leulmi Marianne Jarzaguet Agnes Claustre Lydie Combaret Daniel Béchet Anne‐Elisabeth Heng Didier Attaix Daniel Taillandier

BACKGROUND Skeletal muscle protein loss is an adaptive response to various patho-physiological situations, and the ubiquitin proteasome system (UPS) is responsible for the degradation of the bulk of muscle proteins. The role of E2 ubiquitin-conjugating enzymes is still poorly understood in skeletal muscle. METHODS We screened for E2s expression levels in C2C12 myotubes submitted to the catabo...

2015
Lisha Mou Qiang Zhang Ruiying Diao Zhiming Cai Yaoting Gui

BACKGROUND A variety of genetic variants lead to abnormal human spermatogenesis. The ubiquitin-conjugating enzyme E2B (UBE2B) plays a significant role in spermatogenesis as Ube2b-knockout male mice are infertile. METHODS In this study, we sequenced the exon and promoter region of UBE2B in 776 patients diagnosed with idiopathic azoospermia (IA) and 709 proven fertile men to examine whether UBE...

 ناباروری یک مشکل کلینیکی عمده است که حدود 10 تا 15 درصد زوج ها را در سراسر جهان درگیر می کند. 40 تا 50 درصد ناباروری زوجین مربوط به مردان است که می تواند ناشی از برهم کنش بین فاکتورهای ژنتیکی و محیطی باشد. در %58 -37 از موارد ناباروری در مردان هیچ دلیل قابل شناسایی دیده نمی شود. این گروه در جایگاه ناباروری با منشأ ناشناخته قرار می‌گیرند. ژن UBE2B و تغییرات آن به عنوان یکی از این عوامل ژنتیکی ن...

2014
Yaoting Gui Lisha Mou Qiaoxia Zhang Lihua Yang Yadong Wang Zhiming Cai

Androgen and androgen receptor (AR) play important roles in spermatogenesis, yet detailed androgen/ AR signals in Sertoli cells remain unclear. To identify AR target genes in Sertoli cells, we analyzed the gene expression profiles of testis between mice lacking AR in Sertoli cells (SAR) and their littermate wild-type (WT) mice. Digital gene expression analysis identified 2,276 genes downregulat...

Journal: :Molecular human reproduction 2013
Alexander N Yatsenko Andrew P Georgiadis Lata J Murthy Dolores J Lamb Martin M Matzuk

Oligozoospermia (low sperm count) is a common semen deficiency. However, to date, few genetic defects have been identified to cause this condition. Moreover, even fewer molecular genetic diagnostic tests are available for patients with oligozoospermia in the andrology clinic. Based on animal and gene expression studies of oligozoospermia, several molecular pathways may be disrupted in post-meio...

Journal: :Genetics and molecular research : GMR 2012
Y Hu W Wen J-G Yu S-Q Qu S-S Wang J Liu B-S Li Y Luo

The ubiquitin-conjugating enzyme 2B gene (UBE2B) is involved in the regular and symmetric organization of the fibrous sheath of sperm flagella. This study aimed to examine the relationship between single nucleotide polymorphisms (SNPs) in UBE2B and infertility in Northeast Chinese men. We carried out a polymerase chain reaction-restriction fragment length polymorphism analysis for SNPs in 312 f...

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